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Efficacy of the Vaccine Candidate Based on the P0 Peptide against Dermacentor nitens and Ixodes ricinus Ticks

2023-11-17Journal article Open access
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dc.contributor.authorRodríguez Mallon, A.
dc.contributor.authorEncinosa Guzmán, P.E.
dc.contributor.authorBello, Y.
dc.contributor.authorDomingos, A.
dc.contributor.authorAntunes, S.
dc.contributor.authorKopacek, P.
dc.contributor.authorSantos, A.S.
dc.contributor.authorVelez, R.
dc.contributor.authorPerner, J.
dc.contributor.authorLedesma Bravo, F.L.
dc.contributor.authorFrantova, H.
dc.contributor.authorErhart, J.
dc.contributor.authorRodríguez, R.
dc.contributor.authorFuentes, A.
dc.contributor.authorDiago, D.
dc.contributor.authorJoglar, M.
dc.contributor.authorMéndez, L.
dc.contributor.authorEstrada, M.P.
dc.date.accessioned2024-01-29T14:06:42Z
dc.date.available2024-01-29T14:06:42Z
dc.date.issued2023-11-17
dc.description(This article belongs to the Collection Advances in Tick Research)
dc.description.abstractThe control of ticks through vaccination offers a sustainable alternative to the use of chemicals that cause contamination and the selection of resistant tick strains. However, only a limited number of anti-tick vaccines have reached commercial realization. In this sense, an antigen effective against different tick species is a desirable target for developing such vaccines. A peptide derived from the tick P0 protein (pP0) conjugated to a carrier protein has been demonstrated to be effective against the Rhipicephalus microplus, Rhipicephalus sanguineus, and Amblyomma mixtum tick species. The aim of this work was to assess the efficacy of this peptide when conjugated to the Bm86 protein against Dermacentor nitens and Ixodes ricinus ticks. An RNAi experiment using P0 dsRNA from I. ricinus showed a dramatic reduction in the feeding of injected female ticks on guinea pigs. In the follow-up vaccination experiments, rabbits were immunized with the pP0-Bm86 conjugate and challenged simultaneously with larvae, nymphs, and the adults of I. ricinus ticks. In the same way, horses were immunized with the pP0-Bm86 conjugate and challenged with D. nitens larva. The pP0-Bm86 conjugate showed efficacies of 63% and 55% against I. ricinus and D. nitens ticks, respectively. These results, combined with previous reports of efficacy for this conjugate, show the promising potential for its development as a broad-spectrum anti-tick vaccine.pt_PT
dc.description.sponsorshipThis research was funded by the Center for Genetic Engineering and Biotechnology, Havana, Cuba, the Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Portugal, and the Czech Science Foundation grant no. 20-05736S. Mobility was supported by the CYTED Network INCOGARR 110RT0541.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPathogens. 2023 Nov 17;12(11):1365. doi: 10.3390/pathogens12111365.pt_PT
dc.identifier.doidoi.org/ 10.3390/pathogens12111365pt_PT
dc.identifier.issn2076-0817
dc.identifier.urihttp://hdl.handle.net/10400.18/8986
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2076-0817/12/11/1365pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectTickspt_PT
dc.subjectP0 Proteinpt_PT
dc.subjectAnti-tick Vaccinept_PT
dc.subjectTick Controlpt_PT
dc.subjectVaccinationpt_PT
dc.subjectInfecções Sistémicas e Zoonosespt_PT
dc.titleEfficacy of the Vaccine Candidate Based on the P0 Peptide against Dermacentor nitens and Ixodes ricinus Tickspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue12pt_PT
oaire.citation.startPage1365pt_PT
oaire.citation.titlePathogenspt_PT
oaire.citation.volume11pt_PT
person.familyNameRodríguez Mallon
person.givenNameAlina
person.identifier.orcid0000-0002-6950-6793
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicatione181256a-9cec-4737-bf3b-d58fa546a96e
relation.isAuthorOfPublication.latestForDiscoverye181256a-9cec-4737-bf3b-d58fa546a96e

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