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Portuguese National Serological Survey to Coronavirus Disease-19
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Advisor(s)
Abstract(s)
Introduction: Seroepidemiological studies allow estimating more precise cumulative incidence when compared with results obtained from the SARS-CoV-2 RNA detection test. In this context, the first Portuguese COVID-19 National Serological Survey (ISN-COVID-19) had as primary objectives to: characterize the extent of SARS-CoV-2 infection; determine seroprevalence in specific age groups and Health Regions; and determine the proportion of asymptomatic SARS-CoV-2 infections within Portuguese population.
Methods: ISN-COVID-19 was an observational, cross-sectional study. A non-probabilistic sample of 2,301 people residing in Portugal, aged over 1 year old, was analyzed. Sociodemographic, epidemiological and clinical data were collected using a questionnaire and a blood sample was collected from each participant, at 114 collection points, between May 21-July 8, 2020. SARS-Cov-2 specific IgG and IgM were measured in serum by ELISA.
Results: National seroprevalence was 2.9% (2.0-4.2%), being higher than the accumulated incidence of the infection reported by the National Surveillance System (0.44%). The estimated seroprevalence was higher in males than in females (4.1% vs 1.8%). It ranged from 2.2% (0.8-5.5) in the 10-19 age group to 3.2% (1.5-6.7) in the 40-59 age group. At the regional level, seroprevalence varied between 1.2% (0.3-4.0) in Alentejo and 3.5% (1.9-6.3) in Lisbon and Tagus Valley. Age and regional differences were not statistical significant. About 44% of individuals with SARS-CoV-2 antibodies did not report previous COVID-19 symptoms.
Conclusions: The estimated value is compatible with a limited extent of infection in the Portuguese population, between March and June. Differences observed between seroprevalence and cumulative incidence of the infection are consistent with the evidence of lesser capacity to capture mild or asymptomatic cases by surveillance systems. These results advise universal maintenance of protection measures.
Description
ISN COVID-19 group: Irina Kislaya, Ana Cristina Garcia, Marta Barreto, Ana Rita Torres, Verónica Gómez, Ausenda Machado, Rita Roquette
Mafalda Sousa-Uva, Baltazar Nunes, Carlos Dias, Rita Matos, Paulo Gonçalves, Rita de Sousa, João Santos, Carla Manita, Inês Costa, Sofia Soeiro, Nuno
Verdasca, Carla Roque, Raquel Rocha, Fátima Martins, Jorge Machado, Maria Amélia Frade, Direção da Associação Nacional de Laboratórios (ANL),
Conselho Científico da ANL, Maria José Sousa, Rita Ribeiro, Manuel Carvalho, Sílvia Moreira, Carlos Cardoso, Rui Pinto, Laura Brum, Paula Farto, Marco
Marques, Iolanda Rodrigues, Sofia Jorge, Paula Abreu, Sérgio Fernandes, Maria Beatriz Tomaz, Luísa Ponte, Jorge Queiroz, Edite Gomes, Matilde
Vargues, Maria Edite Caliço, Patrícia Mação, Guiomar Oliveira, Paulo Ávila, Jacinta Dantas, Sofia Miranda, Cátia Silva, Julieta Fernandes, Paula Gama,
Rita Pinto, Pedro Brázio, Ana Paula Marques, Judite Sachicumbi, José Alves, Eurico Gaspar, Fátima Vale, Sofia Reis, Paula Correia, Luísa Sancho, Ana
Margalha Miranda, Maria da Graça Cristina, Alexandra Dias, Cristiana Costa, Francisca Manoel, Isabel Coelho, Eunice Trindade, Elsa Santos, Maria João
Virtuoso, Rita Pereira, Rute Neves, Maria Pereira, Teresa Luciano.
Abstract disponível em: https://www.escaide.eu/sites/default/files/documents/Escaide2020-abstract-book.pdf
Abstract disponível em: https://www.escaide.eu/sites/default/files/documents/Escaide2020-abstract-book.pdf
Keywords
SARS-CoV-2 COVID-19 COVID-19 Pandemic Seroprevalência Imunidade ISN-COVID-19 Estados de Saúde e de Doença Infecções Respiratórias Portugal Inquérito Serológico Nacional COVID-19