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The use of effect biomarkers in human biomonitoring studies: exposure to hexavalent chromium

2019-07-05Conference object Restricted access
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dc.contributor.authorGomes, Bruno Costa
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorHuuskonen, Pasi
dc.contributor.authorSantonen, Tiina
dc.contributor.authorHuumonen, Katriina
dc.contributor.authorNdaw, Sophie
dc.contributor.authorFernández, Mariana F.
dc.contributor.authorSilva, Maria João
dc.date.accessioned2020-06-09T10:06:58Z
dc.date.available2020-06-09T10:06:58Z
dc.date.issued2019-07-05
dc.description.abstractHexavalent chromium, Cr(VI) is a human carcinogen (Group 1, IARC), and its expo-sure has been associated with increased lung cancer risk, particularly in exposed workers. The general population may be exposed to Cr(VI) through food, drinking water and tobacco smoke. Under the Human Biomonitoring for Europe Initiative (HBM4EU), Cr(VI) has been considered a priority substance, indicating the need for generating and analyzing data on human exposure and effects, both as single sub-stance and in mixtures. Although many epidemiological studies have reported data on human exposure to Cr(VI), comparably fewer included effect biomarkers assess-ment. However, these biomarkers are central to identify early biological effects be-fore the onset of any adverse health effect. Additionally, biomarkers provide a link between human exposure and health outcomes, when considered in an adverse outcome pathway (AOP) perspective. In this work, we present the results of a critical review on the conventional and po-tentially new biomarkers for Cr(VI) early biological effects, which may be linked to adverse health outcomes in humans. The results show that the most frequently analyzed effect biomarkers concerning Cr(VI) exposure have been those associated with oxidative stress and genotoxicity (comet and micronucleus in blood cells). Urinary 8-isoprostane, a marker of lipid pe-roxidation, has also been used to relate Cr(VI) exposure to lung cancer. More recent-ly, single-gene alterations as well as omics-based biomarkers e.g., genomic or epigenomic changes and protein signatures, have been pointed as novel effect bi-omarkers, but they still need to be further developed and validated. In the literature revision, the most important knowledge gaps have also been identi-fied and discussed, such as the need of additional mechanistic data, in the perspec-tive of building an AOP for Cr(VI) occupational exposure and lung cancerpt_PT
dc.description.sponsorshipWork co-funded by the HBM4EU project (GA 733032).pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/6970
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationEuropean Human Biomonitoring Initiative
dc.subjectHexavalent Chromiumpt_PT
dc.subjectEffect Biomarkerspt_PT
dc.subjectHuman Biomonitoringpt_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleThe use of effect biomarkers in human biomonitoring studies: exposure to hexavalent chromiumpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleEuropean Human Biomonitoring Initiative
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/733032/EU
oaire.citation.conferencePlaceBilthoven, The Netherlandspt_PT
oaire.citation.title2nd European Exposure Science Strategy Workshop (ISES Europe), 4-5 July 2019pt_PT
oaire.fundingStreamH2020
person.familyNameGomes
person.familyNameLouro
person.familyNameSilva
person.givenNameBruno
person.givenNameHenriqueta
person.givenNameMaria Joao
person.identifier157627
person.identifier.ciencia-id1110-883F-9181
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.ciencia-id7710-643D-97A3
person.identifier.orcid0000-0002-5632-1095
person.identifier.orcid0000-0001-9744-7332
person.identifier.orcid0000-0002-6060-0716
person.identifier.scopus-author-id6507971479
person.identifier.scopus-author-id55944437600
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsrestrictedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication9bc1bf0d-2e4a-4bfa-91d4-69cb3fad6eeb
relation.isAuthorOfPublication2361a951-8b9a-4b90-92d6-f6384003a242
relation.isAuthorOfPublicationa7763685-7c34-468d-b958-9dd0aca66db4
relation.isAuthorOfPublication.latestForDiscovery9bc1bf0d-2e4a-4bfa-91d4-69cb3fad6eeb
relation.isProjectOfPublication6815dc2d-ef7e-4535-8dd3-5193c8bffba5
relation.isProjectOfPublication.latestForDiscovery6815dc2d-ef7e-4535-8dd3-5193c8bffba5

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