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Antifungal susceptibility of 175 Aspergillus isolates from various clinical and environmental sources

2016-10-01Journal article Restricted access
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dc.contributor.authorSabino, Raquel
dc.contributor.authorCarolino, Elisabete
dc.contributor.authorVeríssimo, Cristina
dc.contributor.authorMartinez, Marife
dc.contributor.authorClemons, Karl V.
dc.contributor.authorStevens, David A.
dc.date.accessioned2017-02-21T11:45:25Z
dc.date.available2017-02-21T11:45:25Z
dc.date.issued2016-10-01
dc.description.abstractSome environmental Aspergillus spp. isolates have been described as resistant to antifungals, potentially causing an emerging medical problem. In the present work, the antifungal susceptibility profile of 41 clinical and 134 environmental isolates of Aspergillus was determined using the CLSI microdilution method. The aim of this study was to compare environmental and clinical isolates with respect to their susceptibility, and assess the potential implications for therapy of isolates encountered in different environments. To our knowledge, this is the first report comparing antifungal susceptibility profiles of Aspergillus collected from different environmental sources (poultries, swineries, beach sand, and hospital environment). Significant differences were found in the distribution of the different species sections for the different sources. Significant differences were also found in the susceptibility profile of the different Aspergillus sections recovered from the various sources. Clear differences were found between the susceptibility of clinical and environmental isolates for caspofungin, amphotericin B and posaconazole, with clinical isolates showing overall greater susceptibility, except for caspofungin. In comparison to clinical isolates, hospital environmental isolates showed significantly less susceptibility to amphotericin B and posaconazole. These data indicate that species section identity and the site from which the isolate was recovered influence the antifungal susceptibility profile, which may affect initial antifungal choices.pt_PT
dc.description.sponsorshipRaquel Sabino was financially supported by a fellowship from Fundação para a Ciência e Tecnologia (FCT) Portugal (contract ˆSFRH/BPD/72775/2010).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMed Mycol. 2016 Oct 1;54(7):740-56. doi: 10.1093/mmy/myw024. Epub 2016 May 3pt_PT
dc.identifier.doi10.1093/mmy/myw024pt_PT
dc.identifier.issn1369-3786
dc.identifier.urihttp://hdl.handle.net/10400.18/4302
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherOxford University Press/International Society for Human and Animal Mycology (ISHAM)pt_PT
dc.relation.publisherversionhttps://academic.oup.com/mmy/article-abstract/54/7/740/2222572/Antifungal-susceptibility-of-175-Aspergillus?redirectedFrom=fulltextpt_PT
dc.subjectAspergilluspt_PT
dc.subjectAntifungal Susceptibilitypt_PT
dc.subjectClinicalpt_PT
dc.subjectEnvironmentpt_PT
dc.subjectAntifungal Agentpt_PT
dc.subjectAspergillus Siliconpt_PT
dc.subjectDioxide Fowlspt_PT
dc.subjectDomesticpt_PT
dc.subjectInfecções Sistémicas e Zoonosespt_PT
dc.titleAntifungal susceptibility of 175 Aspergillus isolates from various clinical and environmental sourcespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage756pt_PT
oaire.citation.startPage740pt_PT
oaire.citation.titleMedical Mycologypt_PT
oaire.citation.volume54(7)pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

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