Publicação
Genetic variants of CYP2C9 and IL-6 on female infertility
| dc.contributor.author | Cardoso, R. | |
| dc.contributor.author | Gonçalves, A. | |
| dc.contributor.author | da Silva, J.M. | |
| dc.contributor.author | Oliveira, C. | |
| dc.contributor.author | Xavier, P. | |
| dc.contributor.author | Alves, H. | |
| dc.contributor.author | Barros, A. | |
| dc.contributor.author | Botelho, M.C. | |
| dc.date.accessioned | 2017-11-03T14:50:17Z | |
| dc.date.available | 2017-11-03T14:50:17Z | |
| dc.date.issued | 2017-05-08 | |
| dc.description.abstract | AIM: To study the polymorphic variants in CYP2C9*2*3 and the C-174G promoter polymorphism of the IL-6 gene on Infertile Women.BACKGROUND: - Infertility affects 15–20% of couples worldwide. Within the past decades, there has been a steady rise in the treatment of female infertility with several drugs; - The cytochrome P450 (CYP) genes are oxygenases involved in estrogen biosynthesis and metabolism, generation of DNA damaging procarcinogens, and response to anti-estrogen therapies used in female infertility treatments: - Interleukin-6 (IL-6) is a pleiotropic proinflammatory cytokine, highly expressed in the female urogenital tract and reproductive organs. It has been implicated in estrogen metabolism imbalance. | pt_PT |
| dc.description.version | N/A | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.18/4800 | |
| dc.language.iso | eng | pt_PT |
| dc.publisher | Instituto Nacional de Saúde Doutor Ricardo Jorge, IP | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Genetic Variants | pt_PT |
| dc.subject | Female Infertility | pt_PT |
| dc.title | Genetic variants of CYP2C9 and IL-6 on female infertility | pt_PT |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Lisboa, Portugal | pt_PT |
| oaire.citation.title | Dia do Jovem Investigador do Instituto Nacional de Saúde Doutor Ricardo Jorge, 8 maio 2017 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | conferenceObject | pt_PT |
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