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Effectiveness of antimicrobial interventions directed at tackling antimicrobial resistance in animal production: A systematic review and meta-analysis

2023-09Journal article Restricted access
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dc.contributor.authorCosta, Miguel Mendes
dc.contributor.authorCardo, Miguel
dc.contributor.authorRuano, Zita
dc.contributor.authorAlho, Ana Margarida
dc.contributor.authorDinis-Teixeira, José
dc.contributor.authorAguiar, Pedro
dc.contributor.authorLeite, Andreia
dc.date.accessioned2023-10-10T13:19:02Z
dc.date.available2023-10-10T13:19:02Z
dc.date.issued2023-09
dc.descriptionReview
dc.description.abstractBackground: In the last decades, a more prudent and rational use of antimicrobials has been progressively directed towards animal production to reduce antimicrobial selective pressure and antimicrobial resistance (AMR) in microorganisms and safeguard the antimicrobial efficacy of treatments in human medicine. This systematic review evaluated the effectiveness of interventions that have been applied to reduce or improve veterinary antimicrobial usage and aimed at decreasing resistant bacteria in chicken broiler and pig production contexts. Methods: Original articles were identified by searching PubMed™, Scopus™, The Cochrane Library™, and Web of Science™, and grey literature by searching DANS EASY™, WorldCat™ and RCAAP™. Inclusion criteria included: chicken broiler or pig populations (predestined for meat production), interventions intended to reduce/improve antimicrobial use, comparator with standard or no use of antimicrobials, outcomes related to prevalence of resistant bacteria, farm level studies, original data, and analytical observational studies. Data was extracted from eligible studies and meta-analysis using random or fixed effects models was conducted for combinations including type of intervention, bacterial species, production type and animal populations. Models were selected according to heterogeneity between studies. The effectiveness of interventions was assessed using pooled odds ratio of resistance to antimicrobial substances/classes by bacteria for associations between animal populations with and without intervention. Results: A total of 46 studies were eligible for review. For chicken broilers, most interventions were identified as antimicrobial restrictions on all non-therapeutic use (46%), complete restriction (27%), and prohibition on antimicrobials used for growth promotion (23%). As for pig populations, restrictions were mainly observed on all non-therapeutic use (37%), complete restriction (37%) and group treatments (22%). For meta-analysis, 21 studies were pooled after assessment of existing combinations. These combinations demonstrated a protective effect for most antimicrobial classes in Escherichia coli, Campylobacter and Enterococcus isolates from samples of chicken broilers as well in Escherichia coli and Campylobacter spp. from samples of pigs, compared to animals raised under conventional production or without intervention. Increased odds of resistance were only observed for cephalosporins in E. coli and broilers raised without antimicrobials, and to fluoroquinolones and quinolones in Campylobacter and pigs raised without antimicrobials, compared to conventional production. Conclusions: Our study indicates that organic production, antimicrobial-free farms, and group treatment restrictions are recommended for AMR reduction, providing information that may support decision-making to tackle AMR and better reporting to improve comparability of results between studies.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPrev Vet Med. 2023 Sep:218:106002. doi: 10.1016/j.prevetmed.2023.106002. Epub 2023 Aug 18. Reviewpt_PT
dc.identifier.doi10.1016/j.prevetmed.2023.106002pt_PT
dc.identifier.issn0167-5877
dc.identifier.urihttp://hdl.handle.net/10400.18/8681
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/abs/pii/S0167587723001666?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAnimal Productionpt_PT
dc.subjectAntimicrobial Resistancept_PT
dc.subjectAntimicrobial Usagept_PT
dc.subjectIntervention's Effectivenesspt_PT
dc.subjectProtective Effectspt_PT
dc.subjectZoonotic Bacteriapt_PT
dc.subjectResistência aos Antimicrobianospt_PT
dc.subjectBactérias Zoonóticaspt_PT
dc.subjectDeterminantes da Saúde e da Doençapt_PT
dc.subjectPolíticas de Saúdept_PT
dc.subjectSaúde Públicapt_PT
dc.titleEffectiveness of antimicrobial interventions directed at tackling antimicrobial resistance in animal production: A systematic review and meta-analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage106002pt_PT
oaire.citation.titlePreventive Veterinary Medicinept_PT
oaire.citation.volume218pt_PT
person.familyNameLeite
person.givenNameAndreia
person.identifier1052436
person.identifier.ciencia-id2F10-F9A9-E8A7
person.identifier.orcid0000-0003-0843-0630
person.identifier.scopus-author-id57109931300
rcaap.embargofctAcesso de acordo com a política editorial da revistapt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication838ff85b-16c9-4992-b13f-e3099f916717
relation.isAuthorOfPublication.latestForDiscovery838ff85b-16c9-4992-b13f-e3099f916717

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