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Genetic and Epigenetic Alterations Associated With Human Prenatal Tobacco and Environmental Tobacco Smoke Exposure: Protocol for a Systematic Evidence Map

2025-07-14Artigo científico Acesso aberto
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dc.contributor.authorReis, Ana Teresa
dc.contributor.authorMadureira, Joana
dc.contributor.authorTeixeira, João Paulo
dc.contributor.authorCosta, Carla
dc.date.accessioned2026-02-20T15:34:41Z
dc.date.available2026-02-20T15:34:41Z
dc.date.issued2025-07-14
dc.description.abstractObjectives: This protocol outlines the development of a systematic evidence map (SEM) on genetic and epigenetic alterations associated with human prenatal tobacco exposure. The SEM will identify and synthetize epidemiological data on periconceptional and prenatal tobacco exposure associated with genetic (e.g., DNA damage) and epigenetic (e.g., DNA methylation) outcomes. Furthermore, it will describe the available evidence, highlight knowledge clusters, and identify gaps for future research. Methods: Bibliographic databases and grey literature sources will be searched, complemented by reference mining. Predefined inclusion and exclusion criteria will guide study inclusion. Data extraction will include population, exposure, comparator, outcome, funding, study design, confounding factors, and statistical methods. Summarization will include a narrative review, graphical visualization, and an interactive, queryable and open-access table. Results: A pilot study assessed the protocol's feasibility, testing key components, including screening, data extraction, and eligibility criteria. Findings confirmed that the methodology is workable and reliable. Conclusion: This protocol supports a rigorous, reproducible, transparent SEM, aligned with international standards. The comprehensive mapping will support research prioritization and inform public health policies targeting maternal and child health.eng
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support by national funds in the scope of projects UIDB/04750/2020 and LA/P/0064/2020. JM also acknowledges FCT for individual funding (SFRH/BPD/115112/2016).
dc.identifier.citationPublic Health Rev. 2025 Jul 14:46:1606742. doi: 10.3389/phrs.2025.1606742. eCollection 2025
dc.identifier.doi10.3389/phrs.2025.1606742
dc.identifier.eissn2107-6952
dc.identifier.pmid40726774
dc.identifier.urihttp://hdl.handle.net/10400.18/10971
dc.language.isoeng
dc.peerreviewedyes
dc.publisherFrontiers Media
dc.relationEpidemiology Research Unit - Institute of Public Health, University of Porto
dc.relationLaboratory for Integrative and Translational Research in Population Health
dc.relationEarly life exposure to atmospheric air pollutants and potential DNA damage: Consequences on development and childhood outcomes APPEAL
dc.relation.hasversionhttps://www.ssph-journal.org/journals/public-health-reviews/articles/10.3389/phrs.2025.1606742/full
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectEnvironmental Tobacco Smoke
dc.subjectEpigenetics
dc.subjectGenotoxicity
dc.subjectHuman Prenatal Exposure
dc.subjectTobacco
dc.subjectGenotoxicidade Ambiental
dc.titleGenetic and Epigenetic Alterations Associated With Human Prenatal Tobacco and Environmental Tobacco Smoke Exposure: Protocol for a Systematic Evidence Mapeng
dc.typejournal article
dcterms.referenceshttps://www.ssph-journal.org/articles/10.3389/phrs.2025.1606742/full#supplementary-material
dspace.entity.typePublication
oaire.awardNumberUIDB/04750/2020
oaire.awardNumberLA/P/0064/2020
oaire.awardNumberSFRH/BPD/115112/2016
oaire.awardTitleEpidemiology Research Unit - Institute of Public Health, University of Porto
oaire.awardTitleLaboratory for Integrative and Translational Research in Population Health
oaire.awardTitleEarly life exposure to atmospheric air pollutants and potential DNA damage: Consequences on development and childhood outcomes APPEAL
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04750%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0064%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F115112%2F2016/PT
oaire.citation.startPage1606742
oaire.citation.titlePublic Health Reviews
oaire.citation.volume46
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isProjectOfPublication05f4f337-eeba-4c07-82ed-4202b21618a2
relation.isProjectOfPublication18ca3cb0-ef66-4dd8-b45e-4cb0654cd7e8
relation.isProjectOfPublication0c38fa63-8890-47d4-b3d3-1aa47f53b966
relation.isProjectOfPublication.latestForDiscovery05f4f337-eeba-4c07-82ed-4202b21618a2

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