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Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugal

2023-09-11Journal article Open access
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dc.contributor.authorBorges, Vítor
dc.contributor.authorDuque, Mariana Perez
dc.contributor.authorMartins, João Vieira
dc.contributor.authorVasconcelos, Paula
dc.contributor.authorFerreira, Rita
dc.contributor.authorSobral, Daniel
dc.contributor.authorPelerito, Ana
dc.contributor.authorde Carvalho, Isabel Lopes
dc.contributor.authorNúncio, Maria Sofia
dc.contributor.authorBorrego, Maria José
dc.contributor.authorRoemer, Cornelius
dc.contributor.authorNeher, Richard A.
dc.contributor.authorO’Driscoll, Megan
dc.contributor.authorRocha, Raquel
dc.contributor.authorLopo, Sílvia
dc.contributor.authorNeves, Raquel
dc.contributor.authorPalminha, Paula
dc.contributor.authorCoelho, Luís
dc.contributor.authorNunes, Alexandra
dc.contributor.authorIsidro, Joana
dc.contributor.authorPinto, Miguel
dc.contributor.authorSantos, João Dourado
dc.contributor.authorMixão, Verónica
dc.contributor.authorSantos, Daniela
dc.contributor.authorDuarte, Silvia
dc.contributor.authorVieira, Luís
dc.contributor.authorMartins, Fátima
dc.contributor.authorMachado, Jorge
dc.contributor.authorVeríssimo, Vítor Cabral
dc.contributor.authorGrau, Berta
dc.contributor.authorPeralta-Santos, André
dc.contributor.authorNeves, José
dc.contributor.authorCaldeira, Margarida
dc.contributor.authorPestana, Mafalda
dc.contributor.authorFernandes, Cândida
dc.contributor.authorCaria, João
dc.contributor.authorPinto, Raquel
dc.contributor.authorPóvoas, Diana
dc.contributor.authorMaltez, Fernando
dc.contributor.authorSá, Ana Isabel
dc.contributor.authorSalvador, Mafalda Brito
dc.contributor.authorTeófilo, Eugénio
dc.contributor.authorRocha, Miguel
dc.contributor.authorMoneti, Virginia
dc.contributor.authorDuque, Luis Miguel
dc.contributor.authore Silva, Francisco Ferreira
dc.contributor.authorBaptista, Teresa
dc.contributor.authorVasconcelos, Joana
dc.contributor.authorCasanova, Sara
dc.contributor.authorMansinho, Kamal
dc.contributor.authorAlves, João Vaz
dc.contributor.authorAlves, João
dc.contributor.authorSilva, António
dc.contributor.authorAlpalhão, Miguel
dc.contributor.authorBrazão, Cláudia
dc.contributor.authorSousa, Diogo
dc.contributor.authorFilipe, Paulo
dc.contributor.authorPacheco, Patrícia
dc.contributor.authorPeruzzu, Francesca
dc.contributor.authorde Jesus, Rita Patrocínio
dc.contributor.authorFerreira, Luís
dc.contributor.authorMendez, Josefina
dc.contributor.authorJordão, Sofia
dc.contributor.authorDuarte, Frederico
dc.contributor.authorGonçalves, Maria João
dc.contributor.authorPena, Eduarda
dc.contributor.authorSilva, Claúdio Nunes
dc.contributor.authorGuimarães, André Rodrigues
dc.contributor.authorTavares, Margarida
dc.contributor.authorFreitas, Graça
dc.contributor.authorCordeiro, Rita
dc.contributor.authorGomes, João Paulo
dc.date.accessioned2023-10-04T12:16:11Z
dc.date.available2023-10-04T12:16:11Z
dc.date.issued2023-09-11
dc.descriptionFree PMC article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579057/
dc.description.abstractPathogen genome sequencing during epidemics enhances our ability to identify and understand suspected clusters and investigate their relationships. Here, we combine genomic and epidemiological data of the 2022 mpox outbreak to better understand early viral spread, diversification and transmission dynamics. By sequencing 52% of the confirmed cases in Portugal, we identified the mpox virus sublineages with the highest impact on case numbers and fitted them into a global context, finding evidence that several international sublineages probably emerged or spread early in Portugal. We estimated a 62% infection reporting rate and that 1.3% of the population of men who have sex with men in Portugal were infected. We infer the critical role played by sexual networks and superspreader gatherings, such as sauna attendance, in the dissemination of mpox virus. Overall, our findings highlight genomic epidemiology as a tool for the real-time monitoring and control of mpox epidemics, and can guide future vaccine policy in a highly susceptible population.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNat Med. 2023 Sep 11. doi: 10.1038/s41591-023-02542-x. Online ahead of print.pt_PT
dc.identifier.doi10.1038/s41591-023-02542-xpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/8652
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relation.publisherversionhttps://www.nature.com/articles/s41591-023-02542-xpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMpox Viruspt_PT
dc.subjectMPXVpt_PT
dc.subjectViral Zoonosispt_PT
dc.subjectOutbreakpt_PT
dc.subjectGenomic Epidemiologypt_PT
dc.subjectViral Genome Sequencept_PT
dc.subjectPortugalpt_PT
dc.subjectInfectious Diseasespt_PT
dc.subjectInfecções Sistémicas e Zoonosespt_PT
dc.subjectInfecções Emergentes
dc.titleViral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugalpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleNature Medicinept_PT
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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