Internal Ribosome Entry Site-Dependent Translation Dysregulation-Related Diseases

Marques, Rita; Lacerda, Rafaela; Romão, Luísa

http://hdl.handle.net/10400.18/8458

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Authors

Marques, Rita

Lacerda, Rafaela

Romão, Luísa

Abstract(s)

Internal ribosome entry site (IRES)-mediated translation is an alternative mechanism of translation initiation, known for maintaining protein synthesis when canonical translation is impaired. During a stress response, it contributes to cell reprogramming and adaptation to the new environment.

Description

Review
This entry is adapted from 10.3390/biomedicines10081865 (http://repositorio.insa.pt/handle/10400.18/8440)

Keywords

Internal Ribosome Entry Site IRES Trans-acting Factors IRES-based Multicistronic Vectors Antisense Oligonucleotides Neurodegenerative Diseases Muscular Atrophies Expressão Génica Genómica Funcional e Estrutural