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Chorionic villus sampling: 10 years of experience in a University referral center

2020-05Journal article Restricted access
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dc.contributor.authorMartins, Ana Teresa
dc.contributor.authorFrancisco, Carla
dc.contributor.authorCorreia, Hildeberto
dc.contributor.authorCohen, Álvaro
dc.date.accessioned2021-04-07T15:33:59Z
dc.date.available2021-04-07T15:33:59Z
dc.date.issued2020-05
dc.description.abstractObjectives: The purpose of this study was to estimate our center-specific CVS-related miscarriage rate. Methods: This is an observational retrospective study of women submitted to a CVS in our hospital, between January 1st, 2007 and December 31st, 2016. Maternal and pregnancy characteristics, procedure details, genetic results and pregnancy outcomes of all patients were collected. The FMF miscarriage risk algorithm was used to estimate our population expected risk of miscarriage. To establish the procedure-related risk of miscarriage, we compared the observed with the expected miscarriage rate. Results: We had a total number of 1523 women with a singleton pregnancy who did a CVS over the 10-year period. The mean maternal age was 34 years old; the majority of the women was Caucasian, multiparous and had a spontaneous pregnancy. The most common indication for CVS was a high-risk result in the 1st trimester combined screening test. The karyotype was normal in 72,7% of cases, 11,1% were T21 and 7,2% were T13 or T18. In the study group, 33 women were diagnosed with a fetal demise, 435 had a TOP and there were 4 intrauterine deaths and 34 miscarriages. The rate of miscarriage in our population was 3,2% and the expected patient specific risk for miscarriage was 3,0%. There was no statistical significance between the two miscarriage rates p = 0,705. Conclusion: In our study the risk of miscarriage in the CVS group was not significantly different from that the expected patient specific risk (3.2 % vs 3%, p = 0.7). The procedure-related risk of miscarriage was 0,2%, similar to the rates describe in the literature. An accurate risk of pregnancy loss should be used when counseling women for CVS to allow an informed decision.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Gynecol Obstet Hum Reprod. 2020 May;49(5):101715. doi: 10.1016/j.jogoh.2020.101715. Epub 2020 Feb 19.pt_PT
dc.identifier.doi10.1016/j.jogoh.2020.101715pt_PT
dc.identifier.issn2468-7847
dc.identifier.urihttp://hdl.handle.net/10400.18/7655
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/abs/pii/S2468784720300453?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAbortion, Spontaneouspt_PT
dc.subjectAdultpt_PT
dc.subjectChorionic Villi Samplingpt_PT
dc.subjectCorneal Dystrophies, Hereditarypt_PT
dc.subjectFemalept_PT
dc.subjectFetal Deathpt_PT
dc.subjectGenetic Testingpt_PT
dc.subjectHospitals, Universitypt_PT
dc.subjectHumanspt_PT
dc.subjectKaryotypept_PT
dc.subjectNuchal Translucency Measurementpt_PT
dc.subjectPregnancypt_PT
dc.subjectPregnancy Trimester, Firstpt_PT
dc.subjectPrenatal Diagnosispt_PT
dc.subjectRetrospective Studiespt_PT
dc.subjectRiskpt_PT
dc.subjectDoenças Genéticaspt_PT
dc.titleChorionic villus sampling: 10 years of experience in a University referral centerpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue5pt_PT
oaire.citation.startPage101715pt_PT
oaire.citation.titleJournal of Gynecology Obstetrics and Human Reproductionpt_PT
oaire.citation.volume49pt_PT
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

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