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Fibrous shape underlies the mutagenic and carcinogenic potential of nanosilver while surface chemistry affects the biosafety of iron oxide nanoparticles

2016-09-22Journal article Restricted access
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dc.contributor.authorGábelová, A.
dc.contributor.authorEl Yamani, N.
dc.contributor.authorAlonso, T.I.
dc.contributor.authorBuliaková, B.
dc.contributor.authorSrančíková, A.
dc.contributor.authorBábelová, A.
dc.contributor.authorPran, E.R.
dc.contributor.authorFjellsbø, L.M.
dc.contributor.authorElje, E.
dc.contributor.authorYazdani, M.
dc.contributor.authorSilva, M.J.
dc.contributor.authorDušinská, M.
dc.date.accessioned2017-03-10T13:31:43Z
dc.date.available2017-03-10T13:31:43Z
dc.date.issued2016-09-22
dc.description.abstractNowadays engineered nanomaterials (ENMs) are increasingly used in a wide range of commercial products and biomedical applications. Despite this, the knowledge of human potential health risk as well as comprehensive biological and toxicological information is still limited. We have investigated the capacity of two frequently used metallic ENMs, nanosilver and magnetite nanoparticles (MNPs), to induce thymidine kinase (Tk+/−) mutations in L5178Y mouse lymphoma cells and transformed foci in Bhas 42 cells. Two types of nanosilver, spherical nanoparticles (AgNM300) and fibrous (AgNM302) nanorods/wires, and MNPs differing in surface modifications [MNPs coated with sodium oleate (SO-MNPs), MNPs coated with SO + polyethylene glycol (SO-PEG-MNPs) and MNPs coated with SO + PEG + poly(lactide-co-glycolic acid) SO-PEG-PLGA-MNPs] were included in this study. Spherical AgNM300 showed neither mutagenic nor carcinogenic potential. In contrast, silver nanorods/wires (AgNM302) increased significantly the number of both gene mutations and transformed foci compared with the control (untreated) cells. Under the same treatment conditions, neither SO-MNPs nor SO-PEG-PLGA-MNPs increased the mutant frequency compared with control cells though an equivocal mutagenic effect was estimated for SOPEG- MNPs. Although SO-MNPs and SO-PEG-MNPs did not show any carcinogenic potential, SO-PEG-PLGA-MNPs increased concentration dependently the number of transformed foci in Bhas 42 cells compared with the control cells. Our results revealed that fibrous shape underlies the mutagenic and carcinogenic potential of nanosilver while surface chemistry affects the biosafety of MNPs. Considering that both nanosilver and MNPs are prospective ENMs for biomedical applications, further toxicological evaluations are warranted to assess comprehensively the biosafety of these nanomaterials.pt_PT
dc.description.sponsorshipFP7 NANoREG (Grant Agreement No. NMP4-LA-2013–310584); FP7 QualityNano (Grant Agreement No: INFRA-2010–262163)pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMutagenesis. 2017 Jan;32(1):193-202. doi: 10.1093/mutage/gew045. Epub 2016 Sep 22pt_PT
dc.identifier.doidoi:10.1093/mutage/gew045pt_PT
dc.identifier.issn0267-8357
dc.identifier.urihttp://hdl.handle.net/10400.18/4608
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherOxford University Press/United Kingdom Environmental Mutagen Societypt_PT
dc.relationA pan-European infrastructure for quality in nanomaterials safety testing
dc.relationA common European approach to the regulatory testing of nanomaterials
dc.relation.publisherversionhttps://academic.oup.com/mutage/article-abstract/32/1/193/2630761/Fibrous-shape-underlies-the-mutagenic-and?redirectedFrom=fulltextpt_PT
dc.subjectNanotoxicologypt_PT
dc.subjectNanoparticlespt_PT
dc.subjectNanomaterialspt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleFibrous shape underlies the mutagenic and carcinogenic potential of nanosilver while surface chemistry affects the biosafety of iron oxide nanoparticlespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleA pan-European infrastructure for quality in nanomaterials safety testing
oaire.awardTitleA common European approach to the regulatory testing of nanomaterials
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/262163/EU
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/310584/EU
oaire.citation.endPage202pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage193pt_PT
oaire.citation.titleMutagenesispt_PT
oaire.citation.volume32pt_PT
oaire.fundingStreamFP7
oaire.fundingStreamFP7
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
project.funder.nameEuropean Commission
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication00f3dd6c-2b08-40a0-b7c3-e0bef91647a1
relation.isProjectOfPublicationf9fe5c15-606f-4958-ac4b-8109981d34c7
relation.isProjectOfPublication.latestForDiscoveryf9fe5c15-606f-4958-ac4b-8109981d34c7

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