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earlyMYCO: assessing the risk associated to early-life exposure to mycotoxins

2020-11-18Conference object Restricted access
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dc.contributor.authorAssunção, Ricardo
dc.contributor.authorAlvito, Paula
dc.contributor.authorFerreira, M.
dc.contributor.authorBastos, P.
dc.contributor.authorNunes, C.
dc.contributor.authorDe Boevre, Marthe
dc.contributor.authorDuarte, E.
dc.contributor.authorNunes, B.
dc.contributor.authorNamorado, S.
dc.contributor.authorSilva, S.
dc.contributor.authorPires, S.
dc.contributor.authorMartins, Carla
dc.date.accessioned2021-03-10T08:38:03Z
dc.date.available2021-03-10T08:38:03Z
dc.date.issued2020-11-18
dc.description.abstractA number of health disorders has been associated to exposure to hazardous chemicals during the first 1000 days of life. Therefore, a proper risk assessment built on accurate data assumes particular im-portance to evaluate the potential impact that early-life exposure could represent in adulthood. Mycotox-ins are secondary fungal metabolites that might cause harmful effects in humans and animals. Recent studies showed that Portuguese young children are exposed to multiple mycotoxins through food con-sumption which could constitute a health concern. However, earlier exposure to these compounds re-mains unexplored. earlyMYCO – Early-life exposure to MYCOtoxins and its impact on health, a national funded project, intends to contribute to clarify this issue evaluating the health effects of early-life exposure of Portuguese mother-and-child pairs to mycotoxins and assessing the associated risk. The Estimated Daily Intake, using human biomonitoring data, will be compared with reference dose values. For those mycotoxins representing a health concern, an estimate of the associated probable health-impact will be performed by calculating the associated burden in terms of disability-adjusted life years (DALY). Preliminary results of exposure to mycotoxins through food consumption (cereal-based foods) in young children (≤ 3 years old) revealed a potential adverse health effect for percentiles of intake of aflatoxins above or equal to P50 (corresponding to 0.041 ng/kg body weight/day or higher). Our results will contribute to reach an accurate risk assessment framework and to establish and prioritize preventive measures to reduce exposure to chemicals, especially for vulnerable population groups as pregnant women and infants.pt_PT
dc.description.sponsorshipThis work was funded by FCT/MCTES, PTDC/MED-TOX/28762/2017 and co-funded by CESAM (UIDP/50017/2020+UIDB/50017/2020), through national fundspt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/7394
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationCentre for Environmental and Marine Studies
dc.relationCentre for Environmental and Marine Studies
dc.subjectMycotoxinspt_PT
dc.subjectEarly-life Exposurept_PT
dc.subjectMicotoxinaspt_PT
dc.subjectToxicologia dos Alimentospt_PT
dc.subjectToxicologiapt_PT
dc.subjectSegurança Alimentarpt_PT
dc.subjectAvaliação do Riscopt_PT
dc.subjectearlyMYCOpt_PT
dc.subjectSaúde Humanapt_PT
dc.subjectDeterminantes da Saúde e da Doençapt_PT
dc.titleearlyMYCO: assessing the risk associated to early-life exposure to mycotoxinspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FMED-TOX%2F28762%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50017%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50017%2F2020/PT
oaire.citation.conferencePlaceLisboa, Portugal (online)pt_PT
oaire.citation.title3rd HBM-PT Workshop on Human BioMonitoring in Portugal, INSA, 18 nov 2020pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isProjectOfPublication2635814e-db0a-43c5-b745-a2a237efb72e
relation.isProjectOfPublication4e22de31-8fc5-4b15-b980-3fd0edf5515d
relation.isProjectOfPublication0e72e6c8-b610-43e0-931c-8ad275ad6093
relation.isProjectOfPublication.latestForDiscovery2635814e-db0a-43c5-b745-a2a237efb72e

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