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earlyMYCO – a mother & child cohort in Portugal

2020-12-02Conference object Restricted access
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dc.contributor.authorAssunção, Ricardo
dc.contributor.authorMartins, Carla
dc.contributor.authorCosta, A.
dc.contributor.authorSerrano, D.
dc.contributor.authorDe Boevre, Marthe
dc.contributor.authorVidal, A.
dc.contributor.authorDe Saeger, Sarah
dc.contributor.authorAlvito, Paula
dc.contributor.authorVidigal, C.
dc.contributor.authorAlmeida, E.
dc.contributor.authorNunes, C.
dc.date.accessioned2021-03-10T07:30:17Z
dc.date.available2021-03-10T07:30:17Z
dc.date.issued2020-12-02
dc.description.abstractBackground: Early-life exposure occurs during gestation through transfer of toxic substances present in the maternal diet to the fetus and later on, during lactation, through the breast milk. Food chemical contaminants as mycotoxins are well known carcinogenic, nephrotoxic, hepatotoxic and immunosuppressive compounds. Recent human biomonitoring data revealed that Portuguese population is exposed to mycotoxins. These results emphasized the need for assessing the prenatal and lactation exposure to mycotoxins in a critical and vulnerable period of life. This study aims for the first time in Portugal to assess the early-life exposure to mycotoxins through a mother & child cohort, thus contributing to the knowledge of the exposome of Portuguese population. Methods: Participants are recruited in primary health care units in Lisbon (Portugal) during pregnancy (1st trimester). Four moments of observation are expected within this study: 2nd trimester of pregnancy (mother), and 1st week of life, 1st month of life, 6th month (mother & child). Each moment includes the collection of biological samples (blood, urine, breast milk) and the application of sociodemographic and food consumption questionnaires. Biological samples will be analyzed by liquid chromatography with detection by mass spectrometry for the detection and quantification of 45 mycotoxins’ biomarkers. Results: Data presented include results of mycotoxins’ biomarkers from 12 participants for blood and urine samples. Results obtained will be used to estimate the probable daily intake of each mycotoxin, to perform risk characterization and estimate the burden associated with this exposure. Conclusions: It is expected that results obtained within earlyMYCO will contribute to have a deeper knowledge on exposure of vulnerable population groups (pregnant women and infants) and to understand the impact of early-life exposure to mycotoxins. The biobank will be available for further research and future studies will be developed in order to have a broader knowledge on the exposome of Portuguese population.pt_PT
dc.description.sponsorshipThis work was funded by FCT/MCTES through national funds, to earlyMYCO (PTDC/MED-TOX/28762/2017), and CESAM (UIDP/50017/2020+UIDB/50017/2020).pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/7384
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectEarly-life Exposurept_PT
dc.subjectearlyMYCOpt_PT
dc.subjectGestationpt_PT
dc.subjectToxic Substancespt_PT
dc.subjectSegurança Alimentarpt_PT
dc.subjectToxicologiapt_PT
dc.subjectAvaliação de Riscopt_PT
dc.subjectSaúde Humanapt_PT
dc.subjectPortugalpt_PT
dc.titleearlyMYCO – a mother & child cohort in Portugalpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FMED-TOX%2F28762%2F2017/PT
oaire.citation.conferencePlaceAmsterdam, The Netherlands (online)pt_PT
oaire.citation.title10th International Conference on Children’s Health and the Environment, 1-2 Dec 2020pt_PT
oaire.fundingStream3599-PPCDT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isProjectOfPublication2635814e-db0a-43c5-b745-a2a237efb72e
relation.isProjectOfPublication.latestForDiscovery2635814e-db0a-43c5-b745-a2a237efb72e

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