Publication
Nonsense-Mediated mRNA decay in development, stress and cancer
| dc.contributor.author | Fernandes, Rafael | |
| dc.contributor.author | Nogueira, Gonçalo | |
| dc.contributor.author | da Costa, Paulo J. | |
| dc.contributor.author | Pinto, Francisco | |
| dc.contributor.author | Romão, Luísa | |
| dc.date.accessioned | 2020-04-28T21:43:08Z | |
| dc.date.available | 2020-04-28T21:43:08Z | |
| dc.date.issued | 2019-08-07 | |
| dc.description.abstract | Nonsense-mediated mRNA decay (NMD) is a well characterized eukaryotic mRNA degradation pathway, responsible for the identification and degradation of transcripts harboring translation termination codons in premature contexts. Transcriptome-wide studies revealed that NMD is not only an mRNA surveillance pathway as initially thought, but is also a post-transcriptional regulatory mechanism of gene expression, as it fine-tunes the transcript levels of many wild-type genes. Hence, NMD contributes to the regulation of many essential biological processes, including pathophysiological mechanisms. In this chapter we discuss the importance of NMD and of its regulation to organism development and its link to the cellular stress responses, like the unfolded protein response (UPR) and the integrated stress response (ISR). Additionally, we describe how tumor cells have explored both NMD functions to promote tumorigenesis. Using published data and databases, we have also performed a network-based approach that further supports the link between NMD and these (patho) physiological processes. | pt_PT |
| dc.description.sponsorship | This work was partially supported by Fundação para a Ciência e a Tecnologia (FCT; Portugal) (PTFC/BIM-MEC/3749/2014 to LR and UID/ MULTI/04046/2013 Research Unit grant to BioISI), and by National Institute of Health Dr. Ricardo Jorge. RF is recipient of a fellowship from BioSys PhD programme (SFRH/BD/114392/2016) from FCT (Portugal). GN is recipient of a fellowship from BioSys PhD programme (PD/BD/130959/2017) from FCT (Portugal). PJC is recipient of a fellowship from BioSys PhD programme (PD/BD/52495/2014) from FCT (Portugal). | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Adv Exp Med Biol. 2019;1157:41-83. doi: 10.1007/978-3-030-19966-1_3. Epub 2019 Jul 25 | pt_PT |
| dc.identifier.doi | 10.1007/978-3-030-19966-1_3. | pt_PT |
| dc.identifier.issn | 0065-2598 | |
| dc.identifier.uri | http://hdl.handle.net/10400.18/6544 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Springer Verlag | pt_PT |
| dc.relation.publisherversion | https://link.springer.com/chapter/10.1007%2F978-3-030-19966-1_3 | pt_PT |
| dc.subject | Nonsense-mediated mRNA Decay | pt_PT |
| dc.subject | Gene Expression Regulation | pt_PT |
| dc.subject | Human Disease | pt_PT |
| dc.subject | Integrated Stress Response | pt_PT |
| dc.subject | Tumorigenesis | pt_PT |
| dc.subject | Unfolded Protein Response | pt_PT |
| dc.subject | mRNA Surveillance | pt_PT |
| dc.subject | Genómica Funcional e Estrutural | pt_PT |
| dc.subject | Doenças Genéticas | pt_PT |
| dc.title | Nonsense-Mediated mRNA decay in development, stress and cancer | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04046%2F2013/PT | |
| oaire.citation.endPage | 83 | pt_PT |
| oaire.citation.startPage | 41 | pt_PT |
| oaire.citation.title | Advances in Experimental Medicine and Biology | pt_PT |
| oaire.citation.volume | 1157 | pt_PT |
| oaire.fundingStream | 5876 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.embargofct | De acordo com política editorial da revista. | pt_PT |
| rcaap.rights | embargoedAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isProjectOfPublication | dc84f768-e6f2-4eea-b294-6c8ebbd1a156 | |
| relation.isProjectOfPublication.latestForDiscovery | dc84f768-e6f2-4eea-b294-6c8ebbd1a156 |