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Interplay between glycemia and the genetics of eNOS and ACE for the susceptibility to the onset and development of hypertension on the Portuguese population

2020-12-02Journal article Restricted access
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dc.contributor.authorAguiar, Laura
dc.contributor.authorFerreira, Joana
dc.contributor.authorMatos, Andreia
dc.contributor.authorMascarenhas, Mário Rui
dc.contributor.authorMenezes Falcão, Luiz
dc.contributor.authorFaustino, Paula
dc.contributor.authorBicho, Manuel
dc.contributor.authorInácio, Ângela
dc.date.accessioned2021-03-07T16:43:11Z
dc.date.available2021-12-02T01:30:12Z
dc.date.issued2020-12-02
dc.description.abstractHypertension is a multifactorial condition of genetic and environmental nature. In Portugal the mean prevalence of hypertension in the population is 45.5%. The aim of this study is to evaluate the contribution of anthropometric, physiological and genetic factors (eNOS and ACE) to the development of hypertension in a Portuguese population. A case-control study was conducted in a sample of 377 individuals, 243 hypertensives and 134 normotensives. The polymorphic analyses of intron 4 VNTR in the eNOS gene and the insertion/deletion (I/D) in ACE gene were performed by polymerase chain reaction (PCR). Higher body mass index (BMI) values, higher glycemia and HOMA -IR levels and the 4a allele of the eNOS gene were associated with hypertension. Among the hypertensive group, the allele 4a (eNOS) was associated with higher levels of HbA1c, and the D allele (ACE) with higher glycemia and HOMA-IR levels. Our results highlight the contribution of eNOS and ACE genes as importante players for development of hypertension in the Portuguese population. We believe that a combinatory clinical approach including the traditional anthropomorphic and physiological parameters together with target specific genetic analysis, can be more elucidative in establishing a susceptibility profile on multifactorial conditions as hypertension.pt_PT
dc.description.abstractHighlights: Hypertensive Portuguese have higher levels of BMI, glycemia and HOMA-IR; 4a allele from eNOS is associated with hypertension in the Portuguese population; HbA1c levels are higher in hypertensive Portuguese carrying the 4a allele (eNOS); Glycemia and HOMA-IR levels are higher in Portuguese carrying the D allele (ECA); The interplay between eNOS and ECA genes is an important factor for hypertension.pt_PT
dc.description.sponsorshipFinancial support - Instituto de Investigação Científica Bento da Rocha Cabralpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGene Reports. 2021 Mar;22:100975. doi: 10.1016/j.genrep.2020.100975. Epub 2020 Dec 2.pt_PT
dc.identifier.doi10.1016/j.genrep.2020.100975pt_PT
dc.identifier.eissn2452-0144
dc.identifier.urihttp://hdl.handle.net/10400.18/7355
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S2452014420303897?via%3Dihubpt_PT
dc.subjectGlycemiapt_PT
dc.subjecteNOSpt_PT
dc.subjectACEpt_PT
dc.subjectHypertensionpt_PT
dc.subjectPortugalpt_PT
dc.subjectDoenças Genéticaspt_PT
dc.titleInterplay between glycemia and the genetics of eNOS and ACE for the susceptibility to the onset and development of hypertension on the Portuguese populationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage100975pt_PT
oaire.citation.titleGene Reportspt_PT
oaire.citation.volume22pt_PT
person.familyNameFaustino
person.givenNamePaula
person.identifier.ciencia-idF01A-353A-433E
person.identifier.orcid0000-0002-6269-4867
person.identifier.ridM-3519-2014
person.identifier.scopus-author-id8158641100
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication94303e78-8b7d-4e24-811d-3af3b1a4e330
relation.isAuthorOfPublication.latestForDiscovery94303e78-8b7d-4e24-811d-3af3b1a4e330

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