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Lifestyle, environment and other major determinants of frailty in older adults: a population-based study from the UK Biobank

2025-05-03Artigo científico Acesso aberto
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dc.contributor.authorHemadeh, Ali
dc.contributor.authorLema-Arranz, Carlota
dc.contributor.authorBonassi, Stefano
dc.contributor.authorBuscarini, Leonardo
dc.contributor.authorInfarinato, Francesco
dc.contributor.authorRomano, Paola
dc.contributor.authorFinti, Alessia
dc.contributor.authorMarinozzi, Franco
dc.contributor.authorBini, Fabiano
dc.contributor.authorFernández-Bertólez, Natalia
dc.contributor.authorTeixeira, João Paulo
dc.contributor.authorLorenzo-López, Laura
dc.contributor.authorValdiglesias, Vanessa
dc.contributor.authorLaffon, Blanca
dc.date.accessioned2026-02-20T16:20:08Z
dc.date.available2026-02-20T16:20:08Z
dc.date.issued2025-05-03
dc.description.abstractFrailty is a geriatric multidimensional syndrome characterized by a loss of physiologic reserves and disproportionate vulnerability to external stressors and associated with increased risk of multiple negative health outcomes. Since frailty can be prevented, controlled, and even reverted in its early stages, identifying the main factors involved in its development is crucial to implement preventive and/or restorative interventions. The aim of this study was to assess the impact of a broad range of parameters, including host factors, lifestyle, diet, and environmental and occupational conditions, on the development of frailty in later life. A cross-sectional study was conducted on 221,896 individuals aged 60 and over classified as non-frail (119,332, 53.8%), pre-frail (93,180, 42.0%), and frail (9384, 4.2%) according to the frailty phenotype. Using principal component analysis and machine learning to streamline the data, significant associations were found between frailty risk and air quality, diet, smoking, working conditions, and heavy alcohol consumption. Early-life factors, including breastfed as a baby and maternal smoking around birth, also emerged as predictors of frailty, which was further characterized by clinical indicators like polypharmacy, levels of C-reactive protein and other biomarkers of inflammageing. This study provided robust and original evidence on the association between a large battery of potential risk factors, from early to later stages of life, and the occurrence of frailty in older age. These results will contribute to the development of effective prevention strategies and facilitate the early detection of individuals at high risk of developing frailty.eng
dc.description.sponsorshipOpen Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This work was supported by the Spanish Ministry of Science and Innovation: MCIN/AEI/10.13039/501100011033 [Grant PID2020-113788RB-I00], Fundación San Rafael, Xunta de Galicia (ED431B 2022/16), and Ministry of Education, Culture and Sport PRX19/00353 (to B.L.). The work of SB, LB, FI, and PR was supported by current research funding from the Ministry of Health (Ricerca Corrente), Rome, Italy. SB was also supported by the Competitive Funding for University Research Projects [Finanziamento competitivo di progetti di ricerca di ateneo (FIN/RIC)] San Raffaele University. Funding for open access charge: Universidade da Coruña/CISUG.
dc.identifier.citationBiogerontology. 2025 May 3;26(3):100. doi: 10.1007/s10522-025-10242-x
dc.identifier.doi10.1007/s10522-025-10242-x
dc.identifier.issn1389-5729
dc.identifier.pmid40317383
dc.identifier.urihttp://hdl.handle.net/10400.18/10975
dc.language.isoen
dc.peerreviewedyes
dc.publisherSpringer
dc.relation.hasversionhttps://link.springer.com/article/10.1007/s10522-025-10242-x
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectEnvironment
dc.subjectFrailty
dc.subjectLifestyle
dc.subjectMachine Learning
dc.subjectPrincipal Component Analysis
dc.subjectDeterminantes da Saúde e da Doença
dc.subjectEstados de Saúde e de Doença
dc.titleLifestyle, environment and other major determinants of frailty in older adults: a population-based study from the UK Biobankpor
dc.typejournal article
dcterms.referenceshttps://static-content.springer.com/esm/art%3A10.1007%2Fs10522-025-10242-x/MediaObjects/10522_2025_10242_MOESM1_ESM.docx
dspace.entity.typePublication
oaire.citation.issue3
oaire.citation.startPage100
oaire.citation.titleBiogerontology
oaire.citation.volume26
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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