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Influenza seroprotection correlates with predominant circulating viruses during 2014/15 and 2015/16 seasons in Portugal

2016-08-24Documento de conferência Acesso aberto
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dc.contributor.authorGuiomar, Raquel
dc.contributor.authorCristóvão, Paula
dc.contributor.authorConde, Patrícia
dc.contributor.authorCosta, Inês
dc.contributor.authorPechirra, Pedro
dc.contributor.authorRodrigues, Ana Paula
dc.contributor.authorPereira da Silva, Susana
dc.contributor.authorNunes, Baltazar
dc.contributor.authorMouro Pinto, Rita
dc.contributor.authorSobrinho Simões, Joana
dc.contributor.authorCosta, Maria do Rosário
dc.contributor.authorGuimarães, João Tiago
dc.contributor.authorRodrigues, Fernando
dc.contributor.authorCorreia, Lurdes
dc.contributor.authorPereira-Vaz, João
dc.contributor.authorCaseiro, Paula
dc.contributor.authorCabral Veloso, Rita
dc.contributor.authorMota Vieira, Luísa
dc.contributor.authorPimentel Couto, Ana Rita
dc.contributor.authorSantos, Margarida
dc.contributor.authorBruges Armas, Jácome
dc.contributor.authorBranquinho, Paula
dc.contributor.authorCorte-Real, Rita
dc.contributor.authorMartins, Luís
dc.contributor.authorCunha, Mário
dc.contributor.authorAlmeida, Sofia
dc.contributor.authorViseu, Regina
dc.contributor.authorInácio, Filipe
dc.contributor.authorPeres, Maria João
dc.contributor.authorMilho, Luís
dc.contributor.authorFernandes, Aida
dc.contributor.authorMaurílio, Manuel
dc.contributor.authorCaldeira, Filomena
dc.contributor.authorSanches, Raquel
dc.contributor.authorDantas, Filipa
dc.contributor.authorFreitas, Ludivina
dc.contributor.authorAndrade, Graça
dc.contributor.authorMota, Paula
dc.date.accessioned2017-02-16T14:26:55Z
dc.date.available2017-02-16T14:26:55Z
dc.date.issued2016-08-24
dc.descriptionRede Portuguesa de Laboratórios para o Diagnóstico da Gripept_PT
dc.description.abstractBACKGROUND: Population immune profile for influenza is highly affected by circulating influenza viruses, thus changing the risk of infection for influenza. This study aims to assess influenza immunity in the Portuguese population by age groups, during 2014 and 2015 and establish a relationship between seroprotection and circulating influenza viruses in 2014/15 and 2015/16 seasons. METHODS: Two cross-sectional studies were developed based on a convenience serum sample collected in June 2014 (n=626) and July 2015 (n=675) in hospitals from mainland and Azores and Madeira.Serums equally represent all age groups. Antibody titers were evaluated by HI assay for strains recommended for seasonal influenza vaccine northern hemisphere,2014/15 and 2015/2016. Seroprevalences were estimated for each strain by age group and the association with seasonal cumulative influenza-like illness (ILI) rates for influenza virus during both seasons was analised. RESULTS: In June 2014 the highest seroprotection was observed for influenza A(H3) (39.0%; 95% CI: 36.2-43.8%) and A(H1)pdm09 (29.7; 95% CI: 26.3-33.4%), with higher levels in children 5-14 years old. In 2014/2015 a dominant circulation of influenza B/Yamagata was observed with high incidence rates in individuals under 65 years old, the ones that had lower seroprotection. Although before the start of the season high protection for A(H3) was observed, the circulation of the new drift A(H3) strains had gained an immunological advantage,in accordance with A(H3) elevated incidence rates observed during 2014/15. In July 2015 the highest seroprotection was observed for influenza B/ Yamagata (55.1%; 95% CI: 51.4-58.9%), 2.4 times the estimated 2014.This increase was even more pronounced in younger (≤ 4 years old), 6.3 times increase in 2015.This fact is in agreement with the predominant influenza B virus detected and the high ILI incidence rate observed in children during 2014/2015 epidemic. Seroprotection levels for influenza A in July 2015 were not significantly different from 2014.During 2015/16 season, influenza A(H1N1)pdm09 was predominant, with high incidence rate in < 65 year old. Influenza B/Victoria lineage,although detected at low levels increased in frequency, in agreement with the lowest level of seroprotection detected in the general population before the start of 2015/2016 season (21.8%; 95% CI: 18.7-24.0%). CONCLUSIONS There was a correlation between virus circulation, incidence rates for each age group and the previous seroprotection for seasonal influenza viruses.Our study highlights the value of measuring the serological profile for influenza to establishe risk groups for infection for which an increase preventive measures, including vaccination, should be fostered.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/4209
dc.language.isoengpt_PT
dc.peerreviewednopt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectInfecções Respiratóriaspt_PT
dc.subjectGripept_PT
dc.subjectEstados de Saúde e de Doençapt_PT
dc.subjectSerologypt_PT
dc.subjectInfluenzapt_PT
dc.titleInfluenza seroprotection correlates with predominant circulating viruses during 2014/15 and 2015/16 seasons in Portugalpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceChicago, USApt_PT
oaire.citation.titleIX Options for the Control of Influenza, 24-28 August 2016pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT

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