Repository logo
 
Publication

Alternative Splicing: Expanding the Landscape of Cancer Biomarkers and Therapeutics

2020-11-27Journal article Open access
Simple item page
dc.contributor.authorBessa, Cláudia
dc.contributor.authorMatos, Paulo
dc.contributor.authorJordan, Peter
dc.contributor.authorGonçalves, Vânia
dc.date.accessioned2021-03-06T15:23:01Z
dc.date.available2021-03-06T15:23:01Z
dc.date.issued2020-11-27
dc.descriptionThis article belongs to the Special Issue Targeting Dysregulated RNA Processing in Cancerpt_PT
dc.description.abstractAlternative splicing (AS) is a critical post-transcriptional regulatory mechanism used by more than 95% of transcribed human genes and responsible for structural transcript variation and proteome diversity. In the past decade, genome-wide transcriptome sequencing has revealed that AS is tightly regulated in a tissue- and developmental stage-specific manner, and also frequently dysregulated in multiple human cancer types. It is currently recognized that splicing defects, including genetic alterations in the spliced gene, altered expression of both core components or regulators of the precursor messenger RNA (pre-mRNA) splicing machinery, or both, are major drivers of tumorigenesis. Hence, in this review we provide an overview of our current understanding of splicing alterations in cancer, and emphasize the need to further explore the cancer-specific splicing programs in order to obtain new insights in oncology. Furthermore, we also discuss the recent advances in the identification of dysregulated splicing signatures on a genome-wide scale and their potential use as biomarkers. Finally, we highlight the therapeutic opportunities arising from dysregulated splicing and summarize the current approaches to therapeutically target AS in cancer.pt_PT
dc.description.sponsorshipWork in the authors’ laboratory was supported by Fundação para a Ciência e a Tecnologia (FCT), Portugal (through grant UID/MULTI/04046/2019 to Research Unit BioISI since January 2019 and grant PTDC/BIA-MOL/28386/2017 to V.G. since October 2018) and by the Portuguese association Maratona da Saúde—Cancro 2014 to P.J. since January 2016.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInt J Mol Sci. 2020 Nov 27;21(23):9032. doi: 10.3390/ijms21239032.pt_PT
dc.identifier.doi10.3390/ijms21239032pt_PT
dc.identifier.issn1661-6596
dc.identifier.urihttp://hdl.handle.net/10400.18/7342
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/21/23/9032pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAlternative Splicingpt_PT
dc.subjectCancerpt_PT
dc.subjectCancer Progressionpt_PT
dc.subjectBiomarkerspt_PT
dc.subjectMutationpt_PT
dc.subjectPre-messenger RNApt_PT
dc.subjectSignal Transductionpt_PT
dc.subjectSplicing Factorpt_PT
dc.subjectTherapeutic Targetpt_PT
dc.subjectTumor Biologypt_PT
dc.subjectVias de Transdução de Sinal e Patologias Associadaspt_PT
dc.titleAlternative Splicing: Expanding the Landscape of Cancer Biomarkers and Therapeuticspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04046%2F2013/PT (2019)
oaire.citation.issue23pt_PT
oaire.citation.startPage9032pt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume21pt_PT
oaire.fundingStream5876
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication0dbd968f-ea65-4a2a-9b40-008aff7adbeb
relation.isProjectOfPublication.latestForDiscovery0dbd968f-ea65-4a2a-9b40-008aff7adbeb

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Rev_AS expands biomarker landscape in cancer_IJMS 2020.pdf
Size:
1.4 MB
Format:
Adobe Portable Document Format
Download

Collections

DGH - Artigos em revistas internacionais