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Applicability of the low-density lipoprotein cholesterol gene score in a south European population
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Orientador(es)
Resumo(s)
Aim: The correct identification of the dyslipidaemia is of great importance
in order to implement specific interventions, especially for
cardiovascular disease (CVD) prevention.
The Global Lipids Genetics Consortium (GLGC) reported 158 loci
associated with lipid traits, by genome-wide association studies
(GWAS), although practical value of GWAS approach is still a
subject of debate, half of these loci are previously known to
influence serum lipid concentrations.
Previous studies (Talmud et al., 2013; Futema et al., 2015) have
demonstrated that the co-inheritance of low-density lipoprotein (LDLC)-raising
alleles from 6 of these SNPs is associated with the
Familial Hypercholesterolaemia (FH) phenotype. Here we
investigated the applicability of the LDL-C genetic risk score in the
Portuguese FH population.
Descrição
Palavras-chave
Dyslipidaemia Cardiovascular Disease Portuguese Population Doenças Cardio e Cérebro-vasculares
Contexto Educativo
Citação
Editora
Instituto Nacional de Saúde Doutor Ricardo Jorge, IP