Repository logo
 
Publication

The key role of Spain in the traffic of West Nile virus lineage 1 strains between Europe and Africa

2024-06-05Research article Open access
Simple item page
dc.contributor.authorAguilera-Sepúlveda, Pilar
dc.contributor.authorCano-Gómez, Cristina
dc.contributor.authorVillalba, Rubén
dc.contributor.authorBorges, Vítor
dc.contributor.authorAgüero, Montserrat
dc.contributor.authorBravo-Barriga, Daniel
dc.contributor.authorFrontera, Eva
dc.contributor.authorJiménez-Clavero, Miguel Ángel
dc.contributor.authorFernández-Pinero, Jovita
dc.date.accessioned2025-03-20T11:59:04Z
dc.date.available2025-03-20T11:59:04Z
dc.date.issued2024-06-05
dc.description.abstractBackground: West Nile Virus (WNV) is a zoonotic arbovirus worldwide spread. Seasonal WNV outbreaks occur in the Mediterranean basin since the late 1990's with ever-increasing incidence. In Southern Spain WNV is endemic, as disease foci - caused by WNV lineage 1 (WNV-L1) strains - occur every year. On the contrary, WNV-L2 is the dominant lineage in Europe, so most European WNV sequences available belong to this lineage, WNV-L1 sequences being still scarce. Methods: To fill this gap, this study reports the genetic characterisation of 27 newly described WNV-L1 strains, involved in outbreaks affecting wild birds and horses during the last decade in South-Western Spain. Results: All strains except one belong to the Western Mediterranean-1 sub-cluster (WMed-1), related phylogenetically to Italian, French, Portuguese, Moroccan and, remarkably, Senegalese strains. This sub-cluster persisted, spread and evolved into three distinguishable WMed-1 phylogenetic groups that co-circulated, notably, in the same province (Cádiz). They displayed different behaviours: from long-term persistence and rapid spread to neighbouring regions within Spain, to long-distance spread to different countries, including transcontinental spread to Africa. Among the different introductions of WNV in Spain revealed in this study, some of them succeeded to get established, some extinguished from the territory shortly afterwards. Furthermore, Spain's southernmost province, Cádiz, constitutes a hotspot for virus incursion. Conclusion: Southern Spain seems a likely scenario for emergence of exotic pathogens of African origin. Therefore, circulation of diverse WNV-L1 variants in Spain prompts for an extensive surveillance under a One Health approach.por
dc.description.sponsorshipThis work was supported by the Spanish INIA-MAPA agreements EG17-141 and AEG21-198, by the INIA grant E-RTA2015-00002-C02-00, AEI grant PID2020-116768RR-C21 and by Extremadura regional project IB16135. Pilar Aguilera-Sepúlveda was funded by a FPI predoctoral fellowship from INIA. Vítor Borges work was co-financed through the DURABLE project. The DURABLE project has been co-funded by the European Union, under the EU4Health Programme (EU4H), Project no. 101102733.
dc.identifier.citationInfect Dis (Lond). 2024 Sep;56(9):743-758. doi: 10.1080/23744235.2024.2348633. Epub 2024 Jun 5
dc.identifier.doi10.1080/23744235.2024.2348633
dc.identifier.issn2374-4243
dc.identifier.pmid38836293
dc.identifier.urihttp://hdl.handle.net/10400.18/10447
dc.language.isoeng
dc.peerreviewedyes
dc.publisherTaylor and Francis
dc.relation101102733
dc.relation.hasversionhttps://www.tandfonline.com/doi/full/10.1080/23744235.2024.2348633
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectFull Genome Sequencing
dc.subjectHorses
dc.subjectMediterranean
dc.subjectPhylogenetic Analysis
dc.subjectPrM-E Sequencing
dc.subjectWest Nile Virus
dc.subjectWild Birds
dc.subjectInfecções Sistémicas e Zoonoses
dc.titleThe key role of Spain in the traffic of West Nile virus lineage 1 strains between Europe and Africapor
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.endPage758
oaire.citation.issue9
oaire.citation.startPage743
oaire.citation.titleInfectious Diseases
oaire.citation.volume56
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
The key role of Spain in the traffic of West Nile virus lineage 1 strains between Europe and Africa.pdf
Size:
3.1 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
4.03 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

DDI - Artigos em revistas internacionais
INSA - Artigos em revistas internacionais