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Regulation of glucose transporters by protein kinases in cancer cells

2017-09-08Conference object Restricted access
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dc.contributor.authorHenriques, Andreia
dc.contributor.authorMatos, Paulo
dc.contributor.authorJordan, Peter
dc.date.accessioned2018-03-05T18:47:22Z
dc.date.available2018-03-05T18:47:22Z
dc.date.issued2017-09-08
dc.descriptionAbstract Review publicado em: EMJ Oncol. 5[1]: pp 50-52.
dc.description.abstractBackground: Cancer cells require increased glucose supply to sustain proliferation. One mechanism involves increased expression of glucose transporter (GLUT) genes. But insulin has revealed that protein phosphorylation is another key mechanism in glucose uptake regulation: insulin binding to responsive cells triggers a signalling cascade with phosphorylation of TBC1D4, a negative regulator of endosomal GLUT trafficking, so that more transporters are inserted into the plasma membrane. Previous work from the host lab has identified the family of WNK protein kinases and shown that WNK1 can also phosphorylate TBC1D4 and promote GLUT translocation to the cell surface. Our objective is to understand the contribution of WNK1 to glucose uptake in colorectal cancer cells.pt_PT
dc.description.sponsorshipFunding Suport by FCT (BioISI grant UID/MULTI/04046/2013 and fellowship SFRH/PD/ BD/106080/2015pt_PT
dc.description.versioninfo:eu-repo/semantics/draftpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/5201
dc.language.isoengpt_PT
dc.subjectCancer Cellpt_PT
dc.subjectWNK Protein Kinasespt_PT
dc.subjectGlucose Transportpt_PT
dc.subjectCancro Coloretalpt_PT
dc.subjectVias de Transdução de Sinal e Patologias Associadas
dc.titleRegulation of glucose transporters by protein kinases in cancer cellspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04046%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/WT/Immunology and Infectious Disease/106080
oaire.citation.conferencePlaceMadrid, Spainpt_PT
oaire.citation.titleESMO 2017- European Society of Medical Oncology annual meeting, 8-12 September 2017pt_PT
oaire.fundingStream5876
oaire.fundingStreamImmunology and Infectious Disease
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/100010269
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameWellcome Trust
rcaap.rightsclosedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isProjectOfPublicationdc84f768-e6f2-4eea-b294-6c8ebbd1a156
relation.isProjectOfPublication6ccd41b5-e549-41a0-864f-6cea6266cbb2
relation.isProjectOfPublication.latestForDiscoverydc84f768-e6f2-4eea-b294-6c8ebbd1a156

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