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COVID-19 Vaccine Effectiveness in Autumn and Winter 2022 to 2023 Among Older Europeans

2024-07-01Journal article Open access
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dc.contributor.authorLaniece Delaunay, Charlotte
dc.contributor.authorMazagatos, Clara
dc.contributor.authorMartínez-Baz, Iván
dc.contributor.authorTúri, Gergő
dc.contributor.authorGoerlitz, Luise
dc.contributor.authorDomegan, Lisa
dc.contributor.authorMeijer, Adam
dc.contributor.authorRodrigues, Ana Paula
dc.contributor.authorSève, Noémie
dc.contributor.authorIlić, Maja
dc.contributor.authorLatorre-Margalef, Neus
dc.contributor.authorLazar, Mihaela
dc.contributor.authorMaurel, Marine
dc.contributor.authorMelo, Aryse
dc.contributor.authorAndreu Ivorra, Blanca
dc.contributor.authorCasado, Itziar
dc.contributor.authorHorváth, Judit Krisztina
dc.contributor.authorBuda, Silke
dc.contributor.authorBennett, Charlene
dc.contributor.authorde Lange, Marit
dc.contributor.authorGuiomar, Raquel
dc.contributor.authorEnouf, Vincent
dc.contributor.authorMlinarić, Ivan
dc.contributor.authorSamuelsson Hagey, Tove
dc.contributor.authorDinu, Sorin
dc.contributor.authorRumayor, Mercedes
dc.contributor.authorCastilla, Jesús
dc.contributor.authorOroszi, Beatrix
dc.contributor.authorDürrwald, Ralf
dc.contributor.authorO’Donnell, Joan
dc.contributor.authorHooiveld, Mariëtte
dc.contributor.authorGómez, Verónica
dc.contributor.authorFalchi, Alessandra
dc.contributor.authorKurečić Filipović, Sanja
dc.contributor.authorDillner, Lena
dc.contributor.authorPopescu, Rodica
dc.contributor.authorBacci, Sabrina
dc.contributor.authorKaczmarek, Marlena
dc.contributor.authorKissling, Esther
dc.contributor.authorGallardo García, Virtudes
dc.contributor.authorPerez Morilla, Esteban
dc.contributor.authorPedrosa Corral, Irene
dc.contributor.authorGarcía Vázquez, Miriam
dc.contributor.authorMilagro-Beamonte, Ana
dc.contributor.authorFernandez Ibañez, Ana
dc.contributor.authorMargolles Martins, Mario
dc.contributor.authorGiménez Duran, Jaume
dc.contributor.authorSastre Palou, Bartolomé
dc.contributor.authorLópez Causapé, Carla
dc.contributor.authorViloria Raymundo, Luis Javier
dc.contributor.authorVega Alonso, Tomás
dc.contributor.authorOrdax Díez, Ana
dc.contributor.authorLozano Alonso, Jose Eugenio
dc.contributor.authorRojo Bello, Silvia
dc.contributor.authorMendioroz, Jacobo
dc.contributor.authorBasile, Luca
dc.contributor.authorMartínez Mateo, Ana Isabel
dc.contributor.authorRuiz de Porras, Carlota
dc.contributor.authorMoya Garcés, Alba
dc.contributor.authorMarcos, Mª Ángeles
dc.contributor.authorLópez Maside, Aurora
dc.contributor.authorBotella Quijal, Francesc
dc.contributor.authorMiralles Espi, Maite
dc.contributor.authorAndreu Salete, Cristina
dc.contributor.authorGarcía Rodríguez, María del Carmen
dc.contributor.authorLinares, Juan Antonio
dc.contributor.authorGarcía Comas, Luis
dc.contributor.authorBarranco, Mª Isabel
dc.contributor.authorChirlaque, María-Dolores
dc.contributor.authorMoreno Docón, Antonio
dc.contributor.authorRamos Marín, Violeta
dc.contributor.authorCastrillejo, Daniel
dc.contributor.authorGómez Anés, Atanasio
dc.contributor.authorLarrauro, Amparo
dc.contributor.authorPérez-Gimeno, Gloria
dc.contributor.authorLozano Álvarez, Marcos
dc.contributor.authorVega, Lorena
dc.contributor.authorGalindo, Silvia
dc.contributor.authorPuma, Tania
dc.contributor.authorMonge, Susana
dc.contributor.authorPozo, Francisco
dc.contributor.authorCasas, Inmaculada
dc.contributor.authorSandonis, Virginia
dc.contributor.authorVázquez-Morón, Sonia
dc.contributor.authorEcheverría, Aitziber
dc.contributor.authorTrobajo-Sanmartín, Camino
dc.contributor.authorGarcía Cenoz, Manuel
dc.contributor.authorEzpeleta, Guillermo
dc.contributor.authorEzpeleta, Carmen
dc.contributor.authorNavascués, Ana
dc.contributor.authorKrisztalovics, Katalin
dc.contributor.authorMucsányiné Juhász, Krisztina
dc.contributor.authorKristóf, Katalin
dc.contributor.authorPreuss, Ute
dc.contributor.authorWedde, Marianne
dc.contributor.authorBiere, Barbara
dc.contributor.authorReiche, Janine
dc.contributor.authorOh, Djin-Ye
dc.contributor.authorMcKenna, Adele
dc.contributor.authorConnell, Jeff
dc.contributor.authorJoyce, Michael
dc.contributor.authorBagheri, Mariam
dc.contributor.authorBos, Sanne
dc.contributor.authorvan den Brink, Sharon
dc.contributor.authorDijkstra, Frederika
dc.contributor.authorEggink, Dirk
dc.contributor.authorvan Gageldonk-Lafeber, Rianne
dc.contributor.authorGoderski, Gabriel
dc.contributor.authorHerrebrugh, Chantal
dc.contributor.authorJenniskens, Liz
dc.contributor.authorReukers, Daphne
dc.contributor.authorSluimer, John
dc.contributor.authorSprong, Tara
dc.contributor.authorTeirlinck, Anne
dc.contributor.authorVeldhijzen, Nienke
dc.contributor.authorvan der Burgh, Ruben
dc.contributor.authorKager, Cathrien
dc.contributor.authorKlinkhamer, Mayra
dc.contributor.authorKnottnerus, Bart
dc.contributor.authorRiethof, Marloes
dc.contributor.authorvan den Broek, Ruud
dc.contributor.authorWortel, Safira
dc.contributor.authorMachado, Ausenda
dc.contributor.authorKislaya, Irina
dc.contributor.authorAniceto, Carlos
dc.contributor.authorGomes, Licínia
dc.contributor.authorVerdasca, Nuno
dc.contributor.authorHenriques, Camila
dc.contributor.authorDias, Daniela
dc.contributor.authorLança, Miguel
dc.contributor.authorBlanchon, Thierry
dc.contributor.authorGuerrisi, Caroline
dc.contributor.authorRenard, Aubane
dc.contributor.authorLaunay, Titouan
dc.contributor.authorMasse, Shirley
dc.contributor.authorChazelle, Marie
dc.contributor.authorFerenčak, Ivana
dc.contributor.authorKaić, Bernard
dc.contributor.authorVišekruna Vučina, Vesna
dc.contributor.authorČusek Adamić, Katica
dc.contributor.authorKosanović Ličina, Mirjana Lana
dc.contributor.authorLakošeljac, Danijela
dc.contributor.authorMihin Huskić, Ivana
dc.contributor.authorNonković, Diana
dc.contributor.authorCarnahan, Annasara
dc.contributor.authorHansson-Pihlainen, Eva
dc.contributor.authorArvesen, Elin
dc.contributor.authorNid, Nora
dc.contributor.authorHansen, Anna-Lena
dc.contributor.authorAndersson, Emmi
dc.contributor.authorDillner, Lena
dc.contributor.authorJidovu, Adrian
dc.contributor.authorTimnea, Olivia Carmen
dc.contributor.authorPascu, Cătălina
dc.contributor.authorOprea, Mihaela
dc.contributor.authorBistriceanu, Iulia
dc.contributor.authorIvanciuc, Alina
dc.contributor.authorMihai, Maria Elena
dc.contributor.authorVEBIS Primary Care Vaccine Effectiveness Group
dc.date.accessioned2025-03-10T12:16:36Z
dc.date.available2025-03-10T12:16:36Z
dc.date.issued2024-07-01
dc.description.abstractKey Points: - Question: What was the effectiveness of COVID-19 vaccines administered in autumn and winter 2022 to 2023 against symptomatic SARS-CoV-2 infection among people aged 60 years or older in Europe, and how did different exposed or reference groups affect effectiveness? - Findings: In this case-control study of 9308 primary care patients at 11 European sites, within 3 months of vaccination, all COVID-19 vaccine effectiveness (CVE) estimates were 29% to 39% against SARS-CoV-2 viruses and 44% to 52% against the XBB variants. All point estimates decreased by time after vaccination, with no vaccine protection after 6 months. - Meaning: Findings of this study suggest that COVID-19 vaccination campaigns should precede peaks in SARS-CoV-2 incidence and that effectiveness of new vaccines against emerging variants should be continually monitored using seasonal CVE approaches.por
dc.description.abstractImportance: In the context of emerging SARS-CoV-2 variants or lineages and new vaccines, it is key to accurately monitor COVID-19 vaccine effectiveness (CVE) to inform vaccination campaigns. Objective: To estimate the effectiveness of COVID-19 vaccines administered in autumn and winter 2022 to 2023 against symptomatic SARS-CoV-2 infection (with all circulating viruses and XBB lineage in particular) among people aged 60 years or older in Europe, and to compare different CVE approaches across the exposed and reference groups used. Design, setting, and participants: This case-control study obtained data from VEBIS (Vaccine Effectiveness, Burden and Impact Studies), a multicenter study that collects COVID-19 and influenza data from 11 European sites: Croatia; France; Germany; Hungary; Ireland; Portugal; the Netherlands; Romania; Spain, national; Spain, Navarre region; and Sweden. Participants were primary care patients aged 60 years or older with acute respiratory infection symptoms who were recruited at the 11 sites after the start of the COVID-19 vaccination campaign from September 2022 to August 2023. Cases and controls were defined as patients with positive and negative, respectively, reverse transcription-polymerase chain reaction (RT-PCR) test results. Exposures: The exposure was COVID-19 vaccination. The exposure group consisted of patients who received a COVID-19 vaccine during the autumn and winter 2022 to 2023 vaccination campaign and 14 days or more before symptom onset. Reference group included patients who were not vaccinated during or in the 6 months before the 2022 to 2023 campaign (seasonal CVE), those who were never vaccinated (absolute CVE), and those who were vaccinated with at least the primary series 6 months or more before the campaign (relative CVE). For relative CVE of second boosters, patients receiving their second booster during the campaign were compared with those receiving 1 booster 6 months or more before the campaign. Main outcomes and measures: The outcome was RT-PCR-confirmed, medically attended, symptomatic SARS-CoV-2 infection. Four CVE estimates were generated: seasonal, absolute, relative, and relative of second boosters. CVE was estimated using logistic regression, adjusting for study site, symptom onset date, age, chronic condition, and sex. Results: A total of 9308 primary care patients were included, with 1687 cases (1035 females; median [IQR] age, 71 [65-79] years) and 7621 controls (4619 females [61%]; median [IQR] age, 71 [65-78] years). Within 14 to 89 days after vaccination, seasonal CVE was 29% (95% CI, 14%-42%), absolute CVE was 39% (95% CI, 6%-60%), relative CVE was 31% (95% CI, 15% to 44%), and relative CVE of second boosters was 34% (95% CI, 18%-47%) against all SARS-CoV-2 variants. In the same interval, seasonal CVE was 44% (95% CI, -10% to 75%), absolute CVE was 52% (95% CI, -23% to 82%), relative CVE was 47% (95% CI, -8% to 77%), and relative CVE of second boosters was 46% (95% CI, -13% to 77%) during a period of high XBB circulation. Estimates decreased with time since vaccination, with no protection from 180 days after vaccination. Conclusions and relevance: In this case-control study among older Europeans, all CVE approaches suggested that COVID-19 vaccines administered in autumn and winter 2022 to 2023 offered at least 3 months of protection against symptomatic, medically attended, laboratory-confirmed SARS-CoV-2 infection. The effectiveness of new COVID-19 vaccines against emerging SARS-CoV-2 variants should be continually monitored using CVE seasonal approaches.por
dc.description.sponsorshipThis study was funded by framework contract ECDC/2021/019 from the ECDC.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJAMA Netw Open. 2024 Jul 1;7(7):e2419258. doi: 10.1001/jamanetworkopen.2024.19258
dc.identifier.doi10.1001/jamanetworkopen.2024.19258pt_PT
dc.identifier.issn2574-3805
dc.identifier.pmid38949812
dc.identifier.urihttp://hdl.handle.net/10400.18/10423
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Medical Association
dc.relationECDC/2021/019pt_PT
dc.relation.hasversionhttps://jamanetwork.com/journals/jamanetworkopen/fullarticle/2820602
dc.relation.publisherversionhttps://jamanetwork.com/journals/jamanetworkopen/fullarticle/2820602pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCOVID-19pt_PT
dc.subjectSARS-CoV-2
dc.subjectVaccine Effectivenesspt_PT
dc.subjectElderlypt_PT
dc.subjectEurope
dc.subjectInfecções Respiratórias
dc.subjectInvestigação em Serviços de Saúdept_PT
dc.subjectEstados de Saúde e de Doençapt_PT
dc.titleCOVID-19 Vaccine Effectiveness in Autumn and Winter 2022 to 2023 Among Older Europeanspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue7pt_PT
oaire.citation.startPagee2419258
oaire.citation.titleJama Network Open
oaire.citation.volume7pt_PT
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameRodrigues
person.familyNameGuiomar
person.familyNameGOMEZ TEIXEIRA PINTO
person.familyNameMachado
person.familyNamede Carvalho Aniceto
person.familyNameLagoa Gomes
person.familyNameVerdasca
person.familyNameValadas Henriques
person.givenNameAna Paula
person.givenNameRaquel
person.givenNameVERÓNICA DEL PILAR
person.givenNameAusenda
person.givenNameCarlos André
person.givenNameLicínia Isabel
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person.givenNameCamila
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rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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