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Repeated seasonal influenza vaccination among elderly in Europe: effects on laboratory confirmed hospitalised influenza

2017-07-11Journal article Restricted access
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dc.contributor.authorRondy, Marc
dc.contributor.authorLaunay, Odile
dc.contributor.authorCastilla, Jesus
dc.contributor.authorCostanzo, Simona
dc.contributor.authorPuig-Barberà, Joan
dc.contributor.authorGefenaite, Giedre
dc.contributor.authorLarrauri, Amparo
dc.contributor.authorRizzo, Caterina
dc.contributor.authorPitigoi, Daniela
dc.contributor.authorSyrjänen, Ritva K.
dc.contributor.authorMachado, Ausenda
dc.contributor.authorKurečić Filipović, Sanja
dc.contributor.authorKrisztina Horváth, Judit
dc.contributor.authorParadowska-Stankiewicz, Iwona
dc.contributor.authorMarbus, Sierk
dc.contributor.authorInNHOVE/I-MOVE+working group, Alain
dc.contributor.authorMoren
dc.date.accessioned2017-07-18T12:53:36Z
dc.date.available2018-07-12T00:30:15Z
dc.date.issued2017-07-11
dc.description.abstractIn Europe, annual influenza vaccination is recommended to elderly. From 2011 to 2014 and in 2015-16, we conducted a multicentre test negative case control study in hospitals of 11 European countries to measure influenza vaccine effectiveness (IVE) against laboratory confirmed hospitalised influenza among people aged ≥65years. We pooled four seasons data to measure IVE by past exposures to influenza vaccination. We swabbed patients admitted for clinical conditions related to influenza with onset of severe acute respiratory infection ≤7days before admission. Cases were patients RT-PCR positive for influenza virus and controls those negative for any influenza virus. We documented seasonal vaccination status for the current season and the two previous seasons. We recruited 5295 patients over the four seasons, including 465A(H1N1)pdm09, 642A(H3N2), 278 B case-patients and 3910 controls. Among patients unvaccinated in both previous two seasons, current seasonal IVE (pooled across seasons) was 30% (95%CI: -35 to 64), 8% (95%CI: -94 to 56) and 33% (95%CI: -43 to 68) against influenza A(H1N1)pdm09, A(H3N2) and B respectively. Among patients vaccinated in both previous seasons, current seasonal IVE (pooled across seasons) was -1% (95%CI: -80 to 43), 37% (95%CI: 7-57) and 43% (95%CI: 1-68) against influenza A(H1N1)pdm09, A(H3N2) and B respectively. Our results suggest that, regardless of patients' recent vaccination history, current seasonal vaccine conferred some protection to vaccinated patients against hospitalisation with influenza A(H3N2) and B. Vaccination of patients already vaccinated in both the past two seasons did not seem to be effective against A(H1N1)pdm09. To better understand the effect of repeated vaccination, engaging in large cohort studies documenting exposures to vaccine and natural infection is needed.pt_PT
dc.description.sponsorshipThe Lithuanian I-MOVE+ study sites were supported by a grant from the Research Council of Lithuania (SEN-03/2015). The IMOVE+ project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 634446. GlaxoSmithKline, Sanofi Pasteur and Sanofi Pasteur MSD financially supported the InNHOVE network. They had no role in study design, data collection, pooled analysis, and publication. We are grateful to all patients, medical staff, study nurses and epidemiologists from the twelve study sites who actively participated in the study.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationVaccine. 2017 Jul 11. pii: S0264-410X(17)30896-4. doi: 10.1016/j.vaccine.2017.06.088. [Epub ahead of print]pt_PT
dc.identifier.doi10.1016/j.vaccine.2017.06.088pt_PT
dc.identifier.issn0264-410X
dc.identifier.urihttp://hdl.handle.net/10400.18/4753
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationI-MOVE+ Integrated Monitoring of Vaccines Effects in Europe: a platform to measure and compare effectiveness and impact of influenza and pneumococcal vaccines and vaccination strategies in the elderly
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0264410X17308964pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectInfluenza Vaccine Effectivenesspt_PT
dc.subjectRepeated Vaccinationpt_PT
dc.subjectIMOVE+pt_PT
dc.subjectHospitalpt_PT
dc.subjectCuidados de Saúdept_PT
dc.titleRepeated seasonal influenza vaccination among elderly in Europe: effects on laboratory confirmed hospitalised influenzapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleI-MOVE+ Integrated Monitoring of Vaccines Effects in Europe: a platform to measure and compare effectiveness and impact of influenza and pneumococcal vaccines and vaccination strategies in the elderly
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/634446/EU
oaire.citation.endPage4306pt_PT
oaire.citation.issue34pt_PT
oaire.citation.startPage4298pt_PT
oaire.citation.titleVaccinept_PT
oaire.citation.volume35pt_PT
oaire.fundingStreamH2020
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationccfd73a6-6f3c-4702-956c-544973bca97d
relation.isProjectOfPublication.latestForDiscoveryccfd73a6-6f3c-4702-956c-544973bca97d

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