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Single-compound and cumulative risk assessment of mycotoxins present in breakfast cereals consumed by children from Lisbon region, Portugal

2015-11-09Journal article Restricted access
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dc.contributor.authorAssunção, Ricardo
dc.contributor.authorVasco, Elsa
dc.contributor.authorNunes, Baltazar
dc.contributor.authorLoureiro, Susana
dc.contributor.authorMartins, Carla
dc.contributor.authorAlvito, Paula
dc.date.accessioned2015-11-30T11:19:01Z
dc.date.available2015-11-30T11:19:01Z
dc.date.issued2015-11-09
dc.description.abstractHumans can be exposed to multiple chemicals, but current risk assessment is usually carried out on one chemical at a time. Mycotoxins are commonly found in a variety of foods including those intended to consumption by children namely breakfast cereals. The present study aims to perform, the risk assessment of single and multiple mycotoxins present in breakfast cereals consumed by children (1e3 years old) from Lisbon region, Portugal. Daily exposure of children to ochratoxin A, fumonisins and trichothecenes showed no health risks to the children population considering individual mycotoxins, while exposure to aflatoxin B1 (AFB1) suggested a potential health concern for the high percentiles of intake (P90, P95 and P99). The combined exposure to fumonisins and trichothecenes are not expected to be of health concern. The combined margin of exposure (MoET) for the aflatoxins group could constitute a potential health concern and AFB1 was the main contributor for MoET. Legal limits and control strategies regarding the presence of multiple mycotoxins in foodstuffs is an urgent need. To the best of our knowledge, this is the first time a cumulative risk assessment was performed on multiple mycotoxins present in breakfast cereals consumed by children.pt_PT
dc.description.sponsorshipThis research was performed under the MycoMix project “Exploring the toxic effects of mixtures of mycotoxins in infant food and potential health impact” (PTDC/DTP-FTO/0417/2012), and through CESAM: UID/AMB/50017/2013 both funded by the Fundação para a Ciencia e Tecnologia (FCT), Portugal.pt_PT
dc.identifier.citationFood Chem Toxicol. 2015 Dec;86:274-81. doi: 10.1016/j.fct.2015.10.017. Epub 2015 Nov 9pt_PT
dc.identifier.doi10.1016/j.fct.2015.10.017pt_PT
dc.identifier.issn0278-6915
dc.identifier.urihttp://hdl.handle.net/10400.18/3217
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFood and Chemical Toxicologypt_PT
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0278691515300867pt_PT
dc.subjectCumulative Risk Assessmentpt_PT
dc.subjectChildrenpt_PT
dc.subjectMultiple Mycotoxinspt_PT
dc.subjectBreakfast Cerealspt_PT
dc.subjectProbabilistic Analysispt_PT
dc.subjectHuman Healthpt_PT
dc.subjectMycoMixpt_PT
dc.subjectToxicologiapt_PT
dc.subjectSegurança Alimentarpt_PT
dc.titleSingle-compound and cumulative risk assessment of mycotoxins present in breakfast cereals consumed by children from Lisbon region, Portugalpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FDTP-FTO%2F0417%2F2012/PT
oaire.citation.endPage281pt_PT
oaire.citation.startPage274pt_PT
oaire.citation.titleFood and Chemical Toxicologypt_PT
oaire.citation.volume86pt_PT
oaire.fundingStream3599-PPCDT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication7dee8a4a-7112-45ce-a8cb-8c552d7ae061
relation.isProjectOfPublication.latestForDiscovery7dee8a4a-7112-45ce-a8cb-8c552d7ae061

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