Wound healing and cancer progression in Opisthorchis viverrini associated cholangiocarcinoma

Botelho, M.C.; Alves, H.; Richter, J.

http://hdl.handle.net/10400.18/3802

Use this identifier to reference this record.

Name:	Description:	Size:	Format:
Wound healing and cancer progression in Opisthorchis viverrini.pdf		234.95 KB	Adobe PDF	Download

Send Feedback

Authors

Botelho, M.C.

Alves, H.

Richter, J.

Abstract(s)

Infection with the human liver fluke Opisthorchis viverrini induces cancer of the bile ducts, cholangiocarcinoma (CCA). It was shown previously that O. viverrini-secreted proteins accelerate wound resolution in human cholangiocytes. Recombinant Ov-GRN-1 (O. viverrini-derived gene encoding granulin-like growth factor) induced angiogenesis and accelerated mouse wound healing. Given the striking similarities of wound healing and cancer progression, here we discuss the major implications of this finding for an infection-induced cancer of major public health significance in the developing world.