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Publicação
Wound healing and cancer progression in Opisthorchis viverrini associated cholangiocarcinoma
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Autores
Orientador(es)
Resumo(s)
Infection with the human liver fluke Opisthorchis viverrini induces cancer of the bile ducts, cholangiocarcinoma (CCA). It was shown previously that O. viverrini-secreted proteins accelerate wound resolution in human cholangiocytes. Recombinant Ov-GRN-1 (O. viverrini-derived gene encoding granulin-like growth factor) induced angiogenesis and accelerated mouse wound healing. Given the striking similarities of wound healing and cancer progression, here we discuss the major implications of this finding for an infection-induced cancer of major public health significance in the developing world.
Descrição
Letter to the editor
Palavras-chave
Cholangiocarcinoma Opisthorchis viverrini Tumor Progression Wound Healing
Contexto Educativo
Citação
Parasitol Res. 2016 Jul;115(7):2913-4. doi: 10.1007/s00436-016-5090-6. Epub 2016 Apr 30.
Editora
Springer Verlag (Germany)