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Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin

2021-11-05Journal article Open access
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dc.contributor.authorQuerido, Micaela Machado
dc.contributor.authorPaulo, Ivo
dc.contributor.authorHariharakrishnan, Sriram
dc.contributor.authorRocha, Daniel
dc.contributor.authorBarbosa, Nuno
dc.contributor.authorGalhano dos Santos, Rui
dc.contributor.authorBordado, João Moura
dc.contributor.authorTeixeira, João Paulo
dc.contributor.authorPereira, Cristiana Costa
dc.date.accessioned2022-02-03T15:59:48Z
dc.date.available2022-02-03T15:59:48Z
dc.date.issued2021-11-05
dc.descriptionThis article belongs to the Special Issue Nature Inspired Antibiotic Adjuvants to Face the Problem of Multidrug Resistance and Biofilm Infectionspt_PT
dc.description.abstractThe risk of infection arising from indirect sources-namely, contaminated surfaces-has been proved, particularly in healthcare facilities. In the attempt to minimize this problem, innumerable research projects involving the development of surfaces with self-disinfecting properties are being conducted. In this work, wall-paints with self-disinfecting properties were developed with the scope of being applied in environments prone to contamination, such as those at healthcare settings. Our approach was to develop new paint formulations containing two natural plant-based products with known antimicrobial activity-colophony (CLF) and curcumin (CUR). The natural substances were separately incorporated on a commercial paint and their antibacterial activity was evaluated with several bacterial species following ISO 22196. To assess the paints' safety, cytotoxicity tests were performed on HaCaT and A549 cell lines, using tests on extracts and direct contact tests, as suggested by the standardized protocol ISO 10993. In general, both paints containing CLF and CUR were able to reduce the bacterial growth after 24 h, compared with the control, the commercial unmodified paint. Colophony was even able to reduce the number of culturable bacteria by over 2 log for Staphylococcus aureus, Escherichia coli, and Bacillus cereus. Regarding the cytotoxicity tests performed (WST-1, NRU, and LDH), both formulations revealed promising results regardless of the methodology used.pt_PT
dc.description.sponsorshipThis research was funded by Programa Operacional Competitividade e Internacionaliza‐ ção-COMPETE2020/FEDER, towards the project B‐Safecoat (POCI‐01‐0247‐FEDER‐017875), and by FCT (Fundação para a Ciência e Tecnologia) through the PhD grant awarded to M.M.Q. (SFRH/BD/130203/2017).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAntibiotics (Basel). 2021 Nov 5;10(11):1351. doi: 10.3390/antibiotics10111351pt_PT
dc.identifier.doi10.3390/antibiotics10111351pt_PT
dc.identifier.issn2079-6382
dc.identifier.urihttp://hdl.handle.net/10400.18/7919
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationDesinFAST-Self-Disinfecting Paint for Infection Control in Public Spaces
dc.relation.publisherversionhttps://www.mdpi.com/2079-6382/10/11/1351pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntimicrobialpt_PT
dc.subjectColophonypt_PT
dc.subjectCurcuminpt_PT
dc.subjectCytotoxicitypt_PT
dc.subjectPaintpt_PT
dc.subjectSelf-Disinfectingpt_PT
dc.subjectToxicologiapt_PT
dc.titleSelf-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcuminpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDesinFAST-Self-Disinfecting Paint for Infection Control in Public Spaces
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F130203%2F2017/PT
oaire.citation.issue11pt_PT
oaire.citation.startPage1351pt_PT
oaire.citation.titleAntibioticspt_PT
oaire.citation.volume10pt_PT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication8c1a52a8-15d9-4bd0-b94c-8320cbef5a1e
relation.isProjectOfPublication.latestForDiscovery8c1a52a8-15d9-4bd0-b94c-8320cbef5a1e

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