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Frailty syndrome, biomarkers and environmental factors – A pilot study

2020-05-05Journal article Restricted access
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dc.contributor.authorTeixeira-Gomes, Armanda
dc.contributor.authorLage, Bruna
dc.contributor.authorEsteves, Filipa
dc.contributor.authorSousa, Ana Catarina
dc.contributor.authorPastorinho, M. Ramiro
dc.contributor.authorValdiglesias, Vanessa
dc.contributor.authorCosta, Solange
dc.contributor.authorLaffon, Blanca
dc.contributor.authorTeixeira, João Paulo
dc.date.accessioned2021-04-08T11:00:09Z
dc.date.available2021-04-08T11:00:09Z
dc.date.issued2020-05-05
dc.description.abstractFrailty is an age-related syndrome expected to increase over the next decades. This syndrome has been identified to be the most common condition leading to disability, institutionalisation and death in the elderly. The aim of this pilot study is to investigate a possible link between frailty status, biomarkers and environmental exposures. A group of 71 older adults (≥65 years old) was engaged in this study. The study population was classified as 45.1% robust, 45.1% pre-frail and 9.8% frail. A significant higher prevalence of second-hand smokers was found in the pre-frail group when compared to robust. Furthermore, a higher prevalence of robust individuals was found among those consuming home-produced vegetables and water from well/springs. Significant differences were found between data collected in a lifetime exposure questionnaire (LTEQ) and the levels of genotoxicity endpoints and the mercury levels analysed regarding some exposure-related parameters, namely, smoking habits, intake of home-produced vegetables and the use of pesticides in agriculture. Understanding if the way we live(d) or worked can impact the way we age are important questions to be explored. Data obtained in this pilot study encourage further studies on this matter, exploring the role of exposures history and its impact on health.pt_PT
dc.description.abstractHighlights: Frailty is an age-related syndrome expected to increase over the next years; A prevalence of second-hand smokers was found in the pre-frail group; Home-produced vegetables consumers had lower %TDNA levels; Exposure-related factors should be included when studying disease aetiology; The way we live(d) or worked may have an impact on the way we age.pt_PT
dc.description.sponsorshipArmanda Teixeira-Gomes and Solange Costa are supported by Fundação para a Ciência e Tecnologia (FCT-MCTES), and by the European Social Fund, through Programa Operacional Capital Humano (POCH), under the grants SFRH/BD/121802/2016 and SFRH/BPD/ 100948/2014, respectively; Vanessa Valdiglesias is supported by Beatriz Galindo Research FellowshipBEAGAL18/00142. The authors also acknowledge the contribution of the COST Action CA15132 “The comet assay as a human biomonitoring tool (hCOMET)” to this study
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationToxicol Lett. 2020 May 5;330:14-22. doi: 10.1016/j.toxlet.2020.04.023. Online ahead of print.pt_PT
dc.identifier.doi10.1016/j.toxlet.2020.04.023pt_PT
dc.identifier.issn0378-4274
dc.identifier.urihttp://hdl.handle.net/10400.18/7669
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevier/ EUROTOXpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/abs/pii/S0378427420301326?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectDNA Damagept_PT
dc.subjectExposure Historypt_PT
dc.subjectFrailtypt_PT
dc.subjectH2AX Phosphorylationpt_PT
dc.subjectMercurypt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleFrailty syndrome, biomarkers and environmental factors – A pilot studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage22pt_PT
oaire.citation.startPage14pt_PT
oaire.citation.titleToxicology Letterspt_PT
oaire.citation.volume330pt_PT
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

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