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Human herpes virus 6B and mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS): is there a link?

2013-06-17Conference object Restricted access
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dc.contributor.authorLeal, B.
dc.contributor.authorCastelo Branco, R.
dc.contributor.authorRangel, R.
dc.contributor.authorChaves, J.
dc.contributor.authorCarvalho, C.
dc.contributor.authorBettencourt, A.
dc.contributor.authorHonavar, M.
dc.contributor.authorMelo Pires, M.
dc.contributor.authorSantos, A.
dc.contributor.authorMagalhães, T.
dc.contributor.authorLopes, J.
dc.contributor.authorRamalheira, J.
dc.contributor.authorMartins da Silva, A.
dc.contributor.authorCosta, P.P.
dc.contributor.authorMartins da Silva, B.
dc.date.accessioned2014-04-03T12:22:23Z
dc.date.available2014-04-03T12:22:23Z
dc.date.issued2013-06-17
dc.description.abstractPurpose: Human Herpesvirus 6 (HHV-6) is a ubiquitous virus acquired mainly during the first 2 years of life. Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis (MTLE-HS) is the most frequent pharmacoresistant epilepsy. One of the most common antecedents of MTLE-HS is febrile seizures (FS). Although the aetiology of MTLE-HS remains unclear, evidences suggest that HHV-6 infection could be implicated. The objective of this study was to investigate the presence of HHV-6B DNA in the hippocampus and adjoining temporal cortex of MTLE-HS patients submitted to surgery. Methods: A total of 22 MTLE-HS (13 females and nine males) cases were studied. The mean age at surgery was 39 9 years and mean age at onset of seizures was 10 6 years. These study cohort was compared to a group of 10 epileptic patients without MTLE-HS (six females, four males; mean age = 26 15 years) and with autopsy material from nine individuals without neurological disease. HHV-6B DNA was identified by real-time PCR with specific TaqMan probes. Results: We detected HHV-6B DNA in only one hippocampus from a MTLE-HS patient. This patient had a disease duration of 36 years and a history of febrile seizures in childhood. None of the non-MTLE or controls specimens showed positivity for HHV-6B. Conclusions: Our findings do not support a relevant etiologic role for HHV-6B in MTLE-HS, at least in this population. However, the possible role of viral infection in MTLE-HS epileptogenic process, in individual cases, cannot be excluded.por
dc.description.sponsorshipFCT Grant PIC/IC/83297/2007por
dc.identifier.citationEpilepsia.2013;54(S3):135por
dc.identifier.issn0013-9580
dc.identifier.urihttp://hdl.handle.net/10400.18/2223
dc.language.isoengpor
dc.peerreviewednopor
dc.publisherWiley/ International League Against Epilepsypor
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1111/epi.12229/pdfpor
dc.subjectEpilepsypor
dc.subjectMTLEpor
dc.subjectHHV-6por
dc.subjectFebrile Seizurespor
dc.subjectHippocampal Sclerosispor
dc.subjectDeterminantes da Saúde e da Doençapor
dc.subjectDoenças Genéticaspor
dc.titleHuman herpes virus 6B and mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS): is there a link?por
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceMontreal, Canadapor
oaire.citation.endPage135por
oaire.citation.startPage135por
oaire.citation.title30th International Epilepsy Congress, 23-27 June 2013por
oaire.citation.volume54(S3)por
rcaap.rightsrestrictedAccesspor
rcaap.typeconferenceObjectpor

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