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Magnetite nanoparticles functionalized with propolis against methicillin resistant strains of Staphylococcus aureus

2019-06Journal article Restricted access
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dc.contributor.authorEl-Guendouz, Soukaina
dc.contributor.authorLyoussi, Badiaa
dc.contributor.authorLourenço, João P.
dc.contributor.authorRosa da Costa, Ana M.
dc.contributor.authorMiguel, Maria G.
dc.contributor.authorBarrocas Dias, Cristina
dc.contributor.authorManhita, Ana
dc.contributor.authorJordao, Luisa
dc.contributor.authorNogueira, Isabel
dc.contributor.authorFaleiro, Maria L.
dc.date.accessioned2020-04-20T11:15:09Z
dc.date.available2024-09-01T00:31:04Z
dc.date.issued2019-06
dc.description.abstractMagnetite nanoparticles (MNPs) have been evaluated for inhibiting microbial growth and biofilm for- mation. In this study the effect of the nanocomposite Moroccan propolis extract / MNPs acting against methicillin resistant strains of Staphylococcus aureus (MRSA) was evaluated. Chemical composition of propolis was established by pyrolysis coupled to gas chromatography and mass spectrometry method (pyrolysis GC/MS). MNPs were obtained through the co-precipitation method. The fabricated nanostruc- ture was characterized by X-ray Diffraction (DRX), Transmission Electron Microscopy (TEM), and Fourier Transform-Infrared Spectroscopy (FTIR). TEM of MNPs provided a particle average size of 15 nm, FTIR spectral analysis enabled a fast way of identification of MNPs, attesting the occurrence of the different combinations. The use of MNPs loaded with propolis and the antibiotic chloramphenicol at Minimum Inhibitory Concentration (MIC) value inhib- ited the bacterial growth of MSSA (methicillin susceptible strain of S. aureus ) and MRSA strains. After the treatment with MNPs-OA-P-CLo nanocomposite (MNPs with oleic acid, propolis and chloramphenicol), the disruption of the bacterial cell was observed by TEM. The combination of propolis and chlorampheni- col in free form at MIC value largely impaired both MSSA and MRSA strains as, after 2 h of treatment, no viable cells of MRSA 2 and MRSA 16 were recovered. Hence, the results elucidated a new antibac- terial nanocomposite synthesis, for possible applications as prospective nanoantibacterial agents or drug carriers.pt_PT
dc.description.sponsorshipFundação para a Ciência e Tecnologia with the project UID/Multi/04 4 49/2013 (POCI-01-0145-FEDER-007649); UID/BIA/04325/2013–MEDTBIO, UID/BIM/04773/2013 CBMR, UID/QUI/04023/2016, UID/QUI/0 010 0/ 2013, CQE.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Taiwan Inst Chem Eng. 2019 Sep;102:25-33. doi:10.1016/j.jtice.2019.05.018pt_PT
dc.identifier.doi10.1016/j.jtice.2019.05.018pt_PT
dc.identifier.issn1876-107
dc.identifier.urihttp://hdl.handle.net/10400.18/6460
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevier/Taiwan Institute of Chemical Engineerspt_PT
dc.relationUID/QUI/04023/2016pt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/abs/pii/S1876107019302391pt_PT
dc.subjectPyrolysis GC/MSpt_PT
dc.subjectFlavonoidspt_PT
dc.subjectNanotechnologypt_PT
dc.subjectAntibacterial Activitypt_PT
dc.subjectMagnetite Nanoparticlespt_PT
dc.subjectAgentes Microbianos e Ambientept_PT
dc.titleMagnetite nanoparticles functionalized with propolis against methicillin resistant strains of Staphylococcus aureuspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04449%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIA%2F04325%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIM%2F04773%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F00100%2F2013/PT
oaire.citation.endPage33pt_PT
oaire.citation.startPage25pt_PT
oaire.citation.titleJournal of the Taiwan Institute of Chemical Engineerspt_PT
oaire.citation.volume102pt_PT
oaire.fundingStream5876
oaire.fundingStream5876
oaire.fundingStream5876
oaire.fundingStream5876
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctDe acordo com política editorial da revistapt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication0a723852-72c0-479e-b063-b2a97f517adf
relation.isProjectOfPublicationaf4f1a7d-3561-4b3b-88cb-c7c184347d25
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relation.isProjectOfPublication529f1fd6-c195-456c-935d-bbe72c3f6cf1
relation.isProjectOfPublication.latestForDiscoverya31f133b-0667-4228-97e2-00a35cfdea43

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