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Changes in the human genome and epigenome induced by nanomaterials

2021-06-16Conference object Restricted access
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dc.contributor.authorVentura, Célia
dc.contributor.authorVieira, Luís
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorSilva, Maria João
dc.date.accessioned2022-01-14T15:22:27Z
dc.date.available2022-01-14T15:22:27Z
dc.date.issued2021-06-16
dc.descriptionEm co-autoria com a Unidade de Tecnologia e Inovação do DGH.pt_PT
dc.description.abstractHumans are continuously exposed to environmental toxicants that can have an impact in their health. In the last years, several engineered nanomaterials have been incrementally incorporated in a variety of consumer products, and a major public health concern is that nanoscale materials acquire new properties that may elicit human adverse health effects. For instance, several in vivo toxicological studies have shown that nanomaterials as titanium dioxide nanoparticles, nanocellulose or multi-walled carbon nanotubes (MWCNT) may cause pulmonary adverse effects upon inhalation. Nanotoxicology is a challenging field that studies nanomaterials toxicity, which include the assessment of their potential to induce changes in the genome. Some examples of this assessment, using alveolar epithelial human cells and two toxicological assays, the comet assay and the micronucleus assay, which detect double-strand breaks or aneugenic/clastogenic effects, respectively, will be presented. Moreover, recently, some nanomaterials have also demonstrated to cause epigenomic changes, namely, altered DNA methylation or microRNA expression patterns. An epigenomics study, using next generation sequencing, will also be presented. In this study, a profile of differentially expressed miRNAs was identified in the same pulmonary cells after exposure to an occupationally relevant dose of a MWCNT (MWCNT-7). These differently expressed miRNAs indicated some of the molecular mechanisms of action of MWCNT-7. Moreover, miRNA profiling may be explored as a biomarker for monitoring human exposure. Overall, these findings highlight the carcinogenic potential of some nanomaterials and indicate the need of understanding their potential adverse effects to develop effective risk management practices and exclude or reduce the use of hazardous nanomaterials.pt_PT
dc.description.sponsorshipProject ToxApp4NanoCELFI (PTDC/SAU-PUB/32587/2017); ToxOmics (UIDP/00009/2020); GenomePT project (POCI-01-0145-FEDER-022184), supported by COMPETE 2020 - POCI, Lisboa2020, CRESC Algarve2020, through the ERDF, and by FCT.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/7855
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationA predictive toxicology approach to characterize potential respiratory effects of functionalized nanocellulose fibres in a co-culture system
dc.relationCentre for Toxicogenomics and Human Health
dc.subjectNanomaterialspt_PT
dc.subjectEpigenomicspt_PT
dc.subjectNanotoxicologypt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleChanges in the human genome and epigenome induced by nanomaterialspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleA predictive toxicology approach to characterize potential respiratory effects of functionalized nanocellulose fibres in a co-culture system
oaire.awardTitleCentre for Toxicogenomics and Human Health
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-PUB%2F32587%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00009%2F2020/PT
oaire.citation.conferencePlaceMonte da Caparica, Portugalpt_PT
oaire.citation.title5th International Congress of CiiEM (IC CiiEM)- Reducing inequalities in Health and Society, 16-18 junho 2021pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameLouro
person.familyNameSilva
person.givenNameHenriqueta
person.givenNameMaria Joao
person.identifier157627
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.ciencia-id7710-643D-97A3
person.identifier.orcid0000-0001-9744-7332
person.identifier.orcid0000-0002-6060-0716
person.identifier.scopus-author-id6507971479
person.identifier.scopus-author-id55944437600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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