Publication
Invasive Haemophilus influenzae Disease, Europe, 1996-2006
| dc.contributor.author | Ladhani, S. | |
| dc.contributor.author | Slack, M.P. | |
| dc.contributor.author | Heath, P.T. | |
| dc.contributor.author | von Gottberg, A. | |
| dc.contributor.author | Chandra, M. | |
| dc.contributor.author | Ramsay, M.E. | |
| dc.contributor.author | European Union Invasive Bacterial Infection Surveillance participants | |
| dc.date.accessioned | 2011-09-19T10:00:03Z | |
| dc.date.available | 2011-09-19T10:00:03Z | |
| dc.date.issued | 2010-03 | |
| dc.description | European Union Invasive Bacterial Infection Surveillance participants: Paula Lavado (Departamento de Doenças Infecciosas do INSA) | por |
| dc.description.abstract | An international collaboration was established in 1996 to monitor the impact of routine Haemophilus influenzae type b (Hib) vaccination on invasive H. influenzae disease; 14 countries routinely serotype all clinical isolates. Of the 10,081 invasive H. influenzae infections reported during 1996-2006, 4,466 (44%, incidence 0.28 infections/100,000 population) were due to noncapsulated H. influenzae (ncHi); 2,836 (28%, 0.15/100,000), to Hib; and 690 (7%, 0.036/100,000), to non-b encapsulated H. influenzae. Invasive ncHi infections occurred in older persons more often than Hib (median age 58 years vs. 5 years, p<0.0001) and were associated with higher case-fatality ratios (12% vs. 4%, p<0.0001), particularly in infants (17% vs. 3%, p<0.0001). Among non-b encapsulated H. influenzae, types f (72%) and e (21%) were responsible for almost all cases; the overall case-fatality rate was 9%. Thus, the incidence of invasive non-type b H. influenzae is now higher than that of Hib and is associated with higher case fatality. | por |
| dc.description.sponsorship | This study was funded by European Union Biomedicine and Health Research Programme II Reference BMH4960984(1996–1999) | por |
| dc.identifier.citation | Emerg Infect Dis. 2010 Mar;16(3):455-63 | por |
| dc.identifier.issn | 1080-6040 | |
| dc.identifier.other | doi: 10.3201/eid1603.090290 | |
| dc.identifier.uri | http://hdl.handle.net/10400.18/189 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | U.S. National Center for Infectious Diseases | por |
| dc.relation.publisherversion | http://wwwnc.cdc.gov/eid/article/16/3/09-0290_article.htm | por |
| dc.subject | Infecções Respiratórias | por |
| dc.title | Invasive Haemophilus influenzae Disease, Europe, 1996-2006 | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 463 | por |
| oaire.citation.startPage | 455 | por |
| oaire.citation.title | Emerging Infectious Diseases | por |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |
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