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Interaction between HFE and haptoglobin polymorphisms and its relation with plasma glutathione levels in obese children

2019-02-28Journal article Open access
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dc.contributor.authorLaura, Aguiar
dc.contributor.authorMarinho, Cláudia
dc.contributor.authorMartins, Rute
dc.contributor.authorAlho, Irina
dc.contributor.authorFerreira, Joana
dc.contributor.authorQuinhones Levy, Pilar
dc.contributor.authorFaustino, Paula
dc.contributor.authorBicho, Manuel
dc.contributor.authorInácio, Ângela
dc.date.accessioned2020-04-27T08:17:05Z
dc.date.available2020-04-27T08:17:05Z
dc.date.issued2019-02-28
dc.descriptionShort Communicationpt_PT
dc.description.abstractObesity among children has emerged as a serious public health problem. The growing prevalence of childhood obesity has led to the appearance of serious complications, including a chronic systemic inflammation associated with oxidative stress. In the present study, we analysed the interaction between two genes related with iron metabolism - HFE and haptoglobin – and the plasmatic concentration of glutathione, as a way to evaluate the antioxidant response capacity in obesity. To achieve this, 118 obese children and 89 eutrophic children were recruited for the study. Results showed that although obese children present a significantly decreased tGSH levels, once we analysed separately children based on their haptoglobin phenotype, the decreased tGSH levels is significant only for the Hp 2 allele. Additionally, Hp 2.2 obese children carrying H63D polymorphism show significantly lower tGSH/GSSG values. Our results found an association of haptoglobin and HFE with oxidative stress in childhood obesity.pt_PT
dc.description.sponsorshipThe authors are grateful to all study participants and their families and would like to thank the Instituto de Investigação Científica Bento da Rocha Cabral for financial support.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCell Mol Biol (Noisy-le-grand). 2019 Feb 28;65(2):69-74pt_PT
dc.identifier.issn1165-158X
dc.identifier.urihttp://hdl.handle.net/10400.18/6530
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherCMB Association Publisherpt_PT
dc.relation.publisherversionhttps://www.cellmolbiol.org/index.php/CMB/article/view/2442pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nd/4.0/pt_PT
dc.subjectGene Interactionpt_PT
dc.subjectGlutathionept_PT
dc.subjectHFEpt_PT
dc.subjectHaptoglobinpt_PT
dc.subjectInflammationpt_PT
dc.subjectObesitypt_PT
dc.subjectGenética Humanapt_PT
dc.subjectObesidadept_PT
dc.subjectMetabolismo do Ferropt_PT
dc.subjectModificadores Genéticospt_PT
dc.subjectDoenças Genéticaspt_PT
dc.titleInteraction between HFE and haptoglobin polymorphisms and its relation with plasma glutathione levels in obese childrenpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage74pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage69pt_PT
oaire.citation.titleCellular and Molecular Biologypt_PT
oaire.citation.volume65pt_PT
person.familyNameFaustino
person.givenNamePaula
person.identifier.ciencia-idF01A-353A-433E
person.identifier.orcid0000-0002-6269-4867
person.identifier.ridM-3519-2014
person.identifier.scopus-author-id8158641100
rcaap.embargofctDe acordo com política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication94303e78-8b7d-4e24-811d-3af3b1a4e330
relation.isAuthorOfPublication.latestForDiscovery94303e78-8b7d-4e24-811d-3af3b1a4e330

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