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Serological Evidence of Rickettsia Exposure among Patients with Unknown Fever Origin in Angola, 2016-2017

2020-08-24Journal article Open access
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dc.contributor.authorBarradas, P.F.
dc.contributor.authorNeto, Z.
dc.contributor.authorMateus, T.L.
dc.contributor.authorTeodoro, A. C.
dc.contributor.authorDuarte, L.
dc.contributor.authorGonçalves, H.
dc.contributor.authorFerreira, P.
dc.contributor.authorGärtner, F.
dc.contributor.authorSousa, R.
dc.contributor.authorAmorim, I.
dc.date.accessioned2020-10-29T17:04:14Z
dc.date.available2020-10-29T17:04:14Z
dc.date.issued2020-08-24
dc.description.abstractSpotted fever group Rickettsia (SFGR) is one among the aetiologies that cause fever of unknown origin in Angola. Despite their occurrence, there is little information about its magnitude in this country either because it is misdiagnosed or due to the lack of diagnostic resources. For this purpose, eighty-seven selected malaria- and yellow fever-negative serum specimens collected between February 2016 and March 2017 as part of the National Laboratory of Febrile Syndromes, from patients with fever (≥37.5°C) for at least 4 days and of unknown origin, were screened for Rickettsia antibodies through an immunofluorescence assay (IFA). Serological results were interpreted according to the 2017 guidelines for the detection of Rickettsia spp. Three seroreactive patients had detectable IgM antibodies to Rickettsia with an endpoint titre of 32 and IgG antibodies with endpoint titres of 128 and 256. These findings supported a diagnosis of Rickettsia exposure amongst these patients and highlight that rickettsioses may be among the cause of unknown febrile syndromes in Angola. Therefore, physicians must be aware of this reality and must include this vector-borne disease as part of aetiologies that should be considered and systematically tested in order to delineate appropriate strategies of diagnostic and control of Rickettsia in Angola.pt_PT
dc.description.sponsorshipP. Barradas (SFRH/BD/116449/2016) acknowledges the Portuguese Foundation for Science and Technology (FCT) for financial support. IPATIMUP integrates the i3S Research Unit, which was partially supported by FCT. -is work was funded by FEDER Funds -rough the Operational Programme for Competitiveness Factors-COMPETE and National Funds through the FCT, under the project number PEst-C/SAU/LA0003/2013. -is paper was published under the framework of the European Social Fund, Human Resources Development Operational Programme (2007–2013) (POSDRU/159/1.5/S/136893).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInterdiscip Perspect Infect Dis. 2020 Aug 24;2020:4905783. doi: 10.1155/2020/4905783. eCollection 2020.pt_PT
dc.identifier.doi10.1155/2020/4905783pt_PT
dc.identifier.issn1687-708X
dc.identifier.urihttp://hdl.handle.net/10400.18/7230
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherHindawipt_PT
dc.relation.publisherversionhttps://www.hindawi.com/journals/ipid/2020/4905783/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectSpotted fever group Rickettsia (SFGR)pt_PT
dc.subjectRickettsiapt_PT
dc.subjectSerological Evidencept_PT
dc.subjectAngolapt_PT
dc.subjectInfecções Sistémicas e Zoonosespt_PT
dc.titleSerological Evidence of Rickettsia Exposure among Patients with Unknown Fever Origin in Angola, 2016-2017pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/PEst-C%2FSAU%2FLA0003%2F2013/PT
oaire.citation.endPage5pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleInterdisciplinary Perspectives on Infectious Diseasespt_PT
oaire.citation.volume2020pt_PT
oaire.fundingStreamCOMPETE
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationf37b50c3-33c1-479a-a758-f45aa5b3d99f
relation.isProjectOfPublication.latestForDiscoveryf37b50c3-33c1-479a-a758-f45aa5b3d99f

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