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The bactericidal activity of carbon monoxide-releasing molecules against Helicobacter pylori.

2013-12-26Journal article Open access
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dc.contributor.authorTavares, A.F.
dc.contributor.authorParente, M.R.
dc.contributor.authorJustino, M.C.
dc.contributor.authorOleastro, M.
dc.contributor.authorNobre, L.S.
dc.contributor.authorSaraiva, L.M.
dc.date.accessioned2015-02-19T12:49:48Z
dc.date.available2015-02-19T12:49:48Z
dc.date.issued2013-12-26
dc.description.abstractHelicobacter pylori is a pathogen that establishes long life infections responsible for chronic gastric ulcer diseases and a proved risk factor for gastric carcinoma. The therapeutic properties of carbon-monoxide releasing molecules (CORMs) led us to investigate their effect on H. pylori. We show that H. pylori 26695 is susceptible to two widely used CORMs, namely CORM-2 and CORM-3. Also, several H. pylori clinical isolates were killed by CORM-2, including those resistant to metronidazole. Moreover, sub-lethal doses of CORM-2 combined with metronidazole, amoxicillin and clarithromycin was found to potentiate the effect of the antibiotics. We further demonstrate that the mechanisms underpinning the antimicrobial effect of CORMs involve the inhibition of H. pylori respiration and urease activity. In vivo studies done in key cells of the innate immune system, such as macrophages, showed that CORM-2, either alone or when combined with metronidazole, strongly reduces the ability of H. pylori to infect animal cells. Hence, CORMs have the potential to kill antibiotic resistant strains of H. pylori.por
dc.identifier.citationPLoS One. 2013 Dec 26;8(12):e83157. doi: 10.1371/journal.pone.0083157. eCollection 2013por
dc.identifier.doi10.1371/journal.pone.0083157
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10400.18/2915
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherPublic Library of Sciencepor
dc.relation.publisherversionhttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0083157por
dc.subjectHelicobacter pyloripor
dc.subjectCarbon Monoxide-releasing Moleculespor
dc.subjectInfecções Gastrointestinaispor
dc.titleThe bactericidal activity of carbon monoxide-releasing molecules against Helicobacter pylori.por
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPagee83157por
oaire.citation.startPagee83157por
oaire.citation.titlePlos Onepor
oaire.citation.volume8(12)por
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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