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Evaluating efficacy of antimicrobial and antifouling materials for urinary tract medical devices: challenges and recommendations

2019-03-18Journal article Restricted access
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dc.contributor.authorRamstedt, Madeleine
dc.contributor.authorRibeiro, Isabel A.C.
dc.contributor.authorBujdakova, Helena
dc.contributor.authorMergulhão, Filipe J.M.
dc.contributor.authorJordao, Luisa
dc.contributor.authorThomsen, Peter
dc.contributor.authorAlm, Martin
dc.contributor.authorBurmølle, Mette
dc.contributor.authorVladkova, Todorka
dc.contributor.authorCan, Fusun
dc.contributor.authorReches, Meital
dc.contributor.authorRiool, Martijn
dc.contributor.authorBarros, Alexandre
dc.contributor.authorReis, Rui L
dc.contributor.authorMeaurio, Emilio
dc.contributor.authorKikhney, Judith
dc.contributor.authorMoter, Annette
dc.contributor.authorZaat, Sebastian A.J.
dc.contributor.authorSjollema, Jelmer
dc.date.accessioned2020-05-02T16:08:36Z
dc.date.available2020-05-02T16:08:36Z
dc.date.issued2019-03-18
dc.description.abstractIn Europe, the mean incidence of urinary tract infections in intensive care units is 1.1 per 1000 patient-days. Of these cases, catheter-associated urinary tract infections (CAUTI) account for 98%. In total, CAUTI in hospitals is estimated to give additional health-care costs of £1-2.5 billion in the United Kingdom alone. This is in sharp contrast to the low cost of urinary catheters and emphasizes the need for innovative products that reduce the incidence rate of CAUTI. Ureteral stents and other urinary-tract devices suffer similar problems. Antimicrobial strategies are being developed, however, the evaluation of their efficacy is very challenging. This review aims to provide considerations and recommendations covering all relevant aspects of antimicrobial material testing, including surface characterization, biocompatibility, cytotoxicity, in vitro and in vivo tests, microbial strain selection, and hydrodynamic conditions, all in the perspective of complying to the complex pathology of device-associated urinary tract infection. The recommendations should be on the basis of standard assays to be developed which would enable comparisons of results obtained in different research labs both in industry and in academia, as well as provide industry and academia with tools to assess the antimicrobial properties for urinary tract devices in a reliable way.pt_PT
dc.description.sponsorshipEU-funded Trans Domain COST Action, TD 1305 iPROMEDAI (improved protection of medical devices against infection); Project PTDC/BTM-SAL/29335/2017, Portuguese Government, Fundação para a Ciência e Tecnologia (FCT).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMacromol Biosci. 2019 May;19(5):e1800384. doi: 10.1002/mabi.201800384. Epub 2019 Mar 18. Reviewpt_PT
dc.identifier.doi10.1002/mabi.201800384pt_PT
dc.identifier.issn1616-5187
dc.identifier.urihttp://hdl.handle.net/10400.18/6578
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/full/10.1002/mabi.201800384pt_PT
dc.subjectBiofilmspt_PT
dc.subjectMedical Devicespt_PT
dc.subjectHAIpt_PT
dc.subjectUrinary Tract Infectionspt_PT
dc.subjectAntimicrobialpt_PT
dc.subjectIn vitropt_PT
dc.subjectIn vivopt_PT
dc.subjectMaterial Testingpt_PT
dc.titleEvaluating efficacy of antimicrobial and antifouling materials for urinary tract medical devices: challenges and recommendationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceWeinheimpt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPagee1800384pt_PT
oaire.citation.titleMacromolecular Biosciencept_PT
oaire.citation.volume19pt_PT
rcaap.embargofctDe acordo com política editorial da revista.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

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