Repository logo
 
Publication

Setting up a collaborative European human biological monitoring study on occupational exposure to hexavalent chromium

2019-07-10Journal article Restricted access
Simple item page
dc.contributor.authorSantonen, Tiina
dc.contributor.authorAlimonti, Alessandro
dc.contributor.authorBocca, Beatrice
dc.contributor.authorDuca, Radu Corneliu
dc.contributor.authorGalea, Karen S
dc.contributor.authorGodderis, Lode
dc.contributor.authorGöen, Thomas
dc.contributor.authorGomes, Bruno
dc.contributor.authorHanser, Ogier
dc.contributor.authorIavicoli, Ivo
dc.contributor.authorJanasik, Beata
dc.contributor.authorJones, Kate
dc.contributor.authorKiilunen, Mirja
dc.contributor.authorKoch, Holger M
dc.contributor.authorLeese, Elizabeth
dc.contributor.authorLeso, Veruscka
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorNdaw, Sophie
dc.contributor.authorPorras, Simo P
dc.contributor.authorRobert, Alain
dc.contributor.authorRuggieri, Flavia
dc.contributor.authorScheepers, Paul T J
dc.contributor.authorSilva, Maria J
dc.contributor.authorViegas, Susana
dc.contributor.authorWasowicz, Wojciech
dc.contributor.authorCastano, Argelia
dc.contributor.authorSepai, Ovnair
dc.date.accessioned2020-04-29T06:11:34Z
dc.date.available2020-04-29T06:11:34Z
dc.date.issued2019-07-10
dc.description.abstractThe EU human biomonitoring initiative, HBM4EU, aims to co-ordinate and advance human biomonitoring (HBM) across Europe. Within its remit, the project is gathering new, policy relevant, EU-wide data on occupational exposure to relevant priority chemicals and developing new approaches for occupational biomonitoring. In this manuscript, the hexavalent chromium [Cr(VI)] study design is presented as the first example of this HBM4EU approach. This study involves eight European countries and plans to recruit 400 workers performing Cr(VI) surface treatment e.g. electroplating or stainless steel welding activities. The aim is to collect new data on current occupational exposure to Cr(VI) in Europe and to test new methods for Cr biomonitoring, specifically the analysis of Cr(VI) in exhaled breath condensate (EBC) and Cr in red blood cells (RBC) in addition to traditional urinary total Cr analyses. Furthermore, exposure data will be complemented with early biological effects data, including genetic and epigenetic effects. Personal air samples and wipe samples are collected in parallel to help informing the biomonitoring results. We present standard operational procedures (SOPs) to support the harmonized methodologies for the collection of occupational hygiene and HBM samples in different countries.pt_PT
dc.description.abstractHighlights: Pan-European human biomonitoring (HBM) study on occupational exposure to Cr(VI); Harmonized protocols for collecting HBM, occupational hygiene and contextual data; Broad set-up to create meaningful data for EU decision making on Cr(VI) exposure; New biomarkers for exposure to Cr(VI) are piloted; Correlating different exposure parameters to understand the fate of chromium.
dc.description.sponsorshipThis work has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No 733032 and received co-funding from the author’s organizations and/or Ministries.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEnviron Res. 2019 Oct;177:108583. doi: 10.1016/j.envres.2019.108583. Epub 2019 Jul 10pt_PT
dc.identifier.doi10.1016/j.envres.2019.108583pt_PT
dc.identifier.issn0013-9351
dc.identifier.urihttp://hdl.handle.net/10400.18/6556
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevier/ Academic Presspt_PT
dc.relationEuropean Human Biomonitoring Initiative
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0013935119303809?via%3Dihubpt_PT
dc.subjectBiomonitoringpt_PT
dc.subjectHuman Biomonitoringpt_PT
dc.subjectHexavalent chromiumpt_PT
dc.subjectOccupational Exposurept_PT
dc.subjectEffect Markerspt_PT
dc.subjectElectroplatingpt_PT
dc.subjectExhaled Breath Condensatept_PT
dc.subjectMulticenter Studypt_PT
dc.subjectWeldingpt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleSetting up a collaborative European human biological monitoring study on occupational exposure to hexavalent chromiumpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEuropean Human Biomonitoring Initiative
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/733032/EU
oaire.citation.startPage108583pt_PT
oaire.citation.titleEnvironmental Researchpt_PT
oaire.citation.volume177pt_PT
oaire.fundingStreamH2020
person.familyNameLouro
person.givenNameHenriqueta
person.identifier157627
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.orcid0000-0001-9744-7332
person.identifier.scopus-author-id6507971479
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.embargofctDe acordo com política editorial da revista.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication2361a951-8b9a-4b90-92d6-f6384003a242
relation.isAuthorOfPublication.latestForDiscovery2361a951-8b9a-4b90-92d6-f6384003a242
relation.isProjectOfPublication6815dc2d-ef7e-4535-8dd3-5193c8bffba5
relation.isProjectOfPublication.latestForDiscovery6815dc2d-ef7e-4535-8dd3-5193c8bffba5

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Santonen 2019 Cr study design.pdf
Size:
959.73 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

DGH - Artigos em revistas internacionais