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Nirsevimab Effectiveness Against RSV-Related Hospitalisations in Children Under 24 Months: A Test-Negative Case-Control Study in Portugal, 2024-2025

2025-11-30Artigo científico Acesso aberto
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dc.contributor.authorGaio, Vânia
dc.contributor.authorHenriques, Camila
dc.contributor.authorLança, Miguel
dc.contributor.authorMarques, Rita
dc.contributor.authorMarques, Raquel
dc.contributor.authorRodrigues, Marta
dc.contributor.authorAlmeida, Sofia
dc.contributor.authorSousa, Beatriz
dc.contributor.authorFreitas, Margarida
dc.contributor.authorAmaral, Diana
dc.contributor.authorFerreira, Sara
dc.contributor.authorAzevedo, Inês
dc.contributor.authorvon Hafe, Madalena
dc.contributor.authorGonçalves, Rafaela
dc.contributor.authorViseu, Regina
dc.contributor.authorBandeira, Teresa
dc.contributor.authorConstant, Carolina
dc.contributor.authorMalato, Madalena
dc.contributor.authorCarvalho, Inês
dc.contributor.authorRodrigues, Jorge
dc.contributor.authorFarinha, Margarida
dc.contributor.authorNunes, Teresa
dc.contributor.authorGraça, Teresa
dc.contributor.authorGomez, Sofia
dc.contributor.authorSoares, Sara
dc.contributor.authorNeves, João Farela
dc.contributor.authorPaixão, Paulo
dc.contributor.authorPiscalho, Inês
dc.contributor.authorLoureiro, Ana
dc.contributor.authorFreitas, Cristina
dc.contributor.authorAlves, José
dc.contributor.authorSoares, Diana
dc.contributor.authorLopes, Paulo
dc.contributor.authorMachado, Ausenda
dc.contributor.authorGuiomar, Raquel
dc.contributor.authorRodrigues, Ana Paula
dc.contributor.authorVigiRSV Group
dc.date.accessioned2026-01-20T13:01:55Z
dc.date.available2026-01-20T13:01:55Z
dc.date.issued2025-11-30
dc.descriptionVigiRSV Group: Ana Carolina Pinto, Liliana Macedo, Paula Mota, Maria Francisca Santos, Carlota Ferreira, Elsa Melanie dos Santos, Ana Pinto, Tomás Tinoco, Natasha Rosário, Xavier Ferreira, Susana Maia, Inês Lopes, Vânia Soares, Arminda Jorge, Patrícia Ibarzabal, José Alves, Joana Leal, Inês Couto, Beatriz Lourenço, Cláudia Fernandes, Carolina Ferreira, Bruna Barbosa, Catarina Encarnação, Rosário Barreto, Ana Sofia Santos, Marisa Nunes, Raul Martins, Ana Dias Alves, Florbela Cunha, Carla Cruz, Nádia Cavaco e Pedro Fernandes da Gama, Elsa Rocha, Cláudia Calado, Bernardo Camacho, Andreia Afonso e Fátima Pestana, and Raquel Ferreira.
dc.description.abstractWe assessed Nirsevimab effectiveness (NE) against respiratory syncytial virus (RSV)-related hospitalisation in eligible children (< 2 years) using a test-negative case-control design within the VigiRSV network (weeks 43/2024 to 16/2025). Among 341 participants (median age: 2 months; 91.2% without known chronic condition), 137 (40.2%) tested RSV-positive. Adjusted NE against RSV-related hospitalisation was 78.5% (95%CI: 59.3-89.0). Sensitivity analyses confirmed the robustness of the results. These findings support Nirsevimab's effect in a predominantly healthy infant population and contribute to informing public health decisions for RSV immunisation.eng
dc.identifier.citationInfluenza Other Respir Viruses. 2025 Dec;19(12):e70186. doi: 10.1111/irv.70186. Epub 2025 Nov 30
dc.identifier.doi10.1111/irv.70186
dc.identifier.eissn1750-2659
dc.identifier.issn1750-2640
dc.identifier.pmid41320971
dc.identifier.urihttp://hdl.handle.net/10400.18/10722
dc.language.isoeng
dc.peerreviewedyes
dc.publisherWiley
dc.relation.hasversionhttps://onlinelibrary.wiley.com/doi/10.1111/irv.70186
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectRSV
dc.subjectRSV‐Related Hospitalisations
dc.subjectChildren
dc.subjectEffectiveness
dc.subjectNirsevimab
dc.subjectInfecções Respiratórias
dc.subjectDeterminantes da Saúde e da Doença
dc.subjectObservação em Saúde e Vigilância
dc.subjectCuidados de Saúde
dc.subjectPortugal
dc.titleNirsevimab Effectiveness Against RSV-Related Hospitalisations in Children Under 24 Months: A Test-Negative Case-Control Study in Portugal, 2024-2025eng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue12
oaire.citation.startPagee70186
oaire.citation.titleInfluenza and Other Respiratory Viruses
oaire.citation.volume19
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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