Repository logo
 
Publication

Hazard identification and characterization of leachable chemicals from plastic products – a new PARC project

2025-11-27Journal article Open access
Simple item page
dc.contributor.authorDirven, Hubert
dc.contributor.authorBogusz, Aleksandra
dc.contributor.authorHans Bouwmeester
dc.contributor.authorBusch, Mathias
dc.contributor.authorDuflos, Guillaume
dc.contributor.authorEriksen, Gunnar S.
dc.contributor.authorFardilha, Margarida
dc.contributor.authorFlores-Gomez, Daniela
dc.contributor.authorFranko, Nina
dc.contributor.authorGaté, Laurent
dc.contributor.authorGuichard, Yves
dc.contributor.authorSilva, Maria Joao
dc.contributor.authorKamstra, Jorke H.
dc.contributor.authorKasiotis, Konstantinos M.
dc.contributor.authorKim, Sunmi
dc.contributor.authorKim, Young Jun
dc.contributor.authorKim, Youngsam
dc.contributor.authorvan der Koogh, Elise
dc.contributor.authorLoureiro, Susana
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorMachera, Kyriaki
dc.contributor.authorPieters, Raymond H. H.
dc.contributor.authorSpyropoulou, Anastasia
dc.contributor.authorTzanetou, Evangelia N.
dc.contributor.authorMalheiro, Catarina
dc.contributor.authorRavnjak, Tim
dc.contributor.authorRepetto, Guillermo
dc.contributor.authorRivière, Gilles
dc.contributor.authorRyu, Chang Seon
dc.contributor.authorPapadopoulou, Evgenia Anna
dc.contributor.authorAliferis, Konstantinos A.
dc.contributor.authorSolhaug, Anita
dc.contributor.authorSollner Dolenc, Marija
dc.contributor.authorŠtampar, Martina
dc.contributor.authorTavares, Ana M.
dc.contributor.authorTollefsen, Knut Erik
dc.contributor.authorVentura, Célia
dc.contributor.authorWalkowiak, Radoslaw
dc.contributor.authorZobl, Walter
dc.contributor.authorŽegura, Bojana
dc.contributor.authorSnapkow, Igor
dc.contributor.authorHerzke, Dorte
dc.date.accessioned2025-12-03T11:44:21Z
dc.date.available2025-12-03T11:44:21Z
dc.date.issued2025-11-27
dc.descriptionThis article is part of the Research TopicEuropean Partnership on the Assessment of Risks from Chemicals (PARC): Continued Focus on New Approach Methodologies (NAMs) and Data Gap Filling.
dc.description.abstractA recent study has suggested that plastics may contain more than 16,000 chemicals, including additives, processing aids, starting substances, intermediates and Non-Intentionally Added Substances. Plastic chemicals are released throughout the plastic life cycle, from production, use, disposal and recycling. Most of these chemicals have not been studied for potential hazardous properties for humans and in the environment. To refine the risk assessment of these leachable chemicals, additional hazard data are needed. The PlasticLeach project within the EU co-funded Partnership for the Assessment of Risks from Chemicals (PARC) aims to address this data gap by screening several plastic products in daily use. Leachates will be prepared from a number of these plastic items, and these chemical mixtures will be further tested using several test guideline compliant assays and New Approach Methodologies covering both human health and environmental endpoints. The most toxic leachates will be characterized using a non-targeted analysis pipeline to identify chemicals in the leachate. When single chemicals of concern are identified, these will be further tested to determine hazardous properties and identify the respective potency factors to better understand their specific hazard profiles. A tiered approach for hazard testing will be followed. The experimental work will be complemented by toxicological profiling, using publicly available toxicity databases and tools, including Artificial Intelligence tools that cover both human and environmental endpoints. A comprehensive array of endpoints, including cytotoxicity, endocrine disruption, genotoxicity, immunotoxicity, reproductive toxicity and effects related to ecotoxicity will be evaluated. In this paper, we outline the plastic products to be tested and the battery of assays that will be used to identify hazards relevant to both human health and the environment. Data generated from approaches will be reported using standardized formats, stored within a centralized repository, and harmonized to adhere to the FAIR data principles (Findable, Accessible, Interoperable, and Reusable). This integrated strategy will not only advance our understanding of the risks associated with plastic-derived chemicals but will also provide critical support for regulatory decision-making and facilitate the development of safer, and more ecofriendly plastic materials in the future.eng
dc.description.sponsorshipThis work was supported by the author’s institutions and by the Partnership for the Assessment of Risks from Chemicals (PARC) that has received funding from the European Union’s Horizon Europe Research and Innovation Programme under Grant Agreement No. 101057014. The UAVR partner acknowledges national funds through FCT–Fundação para a Ciência e a Tecnologia I.P., under the project CESAM-Centro de Estudos do Ambiente e do Mar, references UID/50017/2025 (doi.org/10.54499/UID/50017/2025) and LA/P/0094/2020 (doi.org/10.54499/LA/P/0094/2020). NIVA acknowledges cofunding from the Research Council of Norway project EXPECT (RCN-315969) and NIVA’s Computational Toxicology Program, NCTP (RCN-342628). NIB is cofinancing the studies by ARIS P1-0245. KRICT is funded by Korea Research Institute of Chemical Technology (KRICT) through Development of Chemical Safety Platform Technologies (Project No. KK2552-10) and the Korea Environment Industry & Technology Institute (KEITI) through the Technology Development Project for Safety Management of Household Chemical Products (RS-2022-KE002056).
dc.identifier.citationFront Toxicol. 2025 Nov 27; 7:1719035. doi: 10.3389/ftox.2025.1719035
dc.identifier.doi10.3389/ftox.2025.1719035
dc.identifier.eissn2673-3080
dc.identifier.urihttp://hdl.handle.net/10400.18/10632
dc.language.isoeng
dc.peerreviewedyes
dc.publisherFrontiers Media
dc.relation101057014
dc.relationUID/50017/2025
dc.relationLA/P/0094/2020
dc.relation.hasversionhttps://www.frontiersin.org/journals/toxicology/articles/10.3389/ftox.2025.1719035/full
dc.relation.ispartofFrontiers in Toxicology
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectEnvironmental Genotoxicity
dc.subjectPARC
dc.subjectPlastics
dc.subjectChemicals
dc.subjectLeachables
dc.subjectHazard Assessment
dc.subjectToxicity
dc.subjectRisk Assessment
dc.subjectNew Approach Methodologies
dc.subjectGenotoxicidade Ambiental
dc.titleHazard identification and characterization of leachable chemicals from plastic products – a new PARC projecteng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage1719035
oaire.citation.titleFrontiers in Toxicology
oaire.citation.volume7
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameSilva
person.familyNameLouro
person.familyNameVentura
person.givenNameMaria Joao
person.givenNameHenriqueta
person.givenNameCélia
person.identifier157627
person.identifier2056460
person.identifier.ciencia-id7710-643D-97A3
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.ciencia-id6116-89BA-C617
person.identifier.orcid0000-0002-6060-0716
person.identifier.orcid0000-0001-9744-7332
person.identifier.orcid0000-0002-0637-2222
person.identifier.scopus-author-id55944437600
person.identifier.scopus-author-id6507971479
relation.isAuthorOfPublicationa7763685-7c34-468d-b958-9dd0aca66db4
relation.isAuthorOfPublication2361a951-8b9a-4b90-92d6-f6384003a242
relation.isAuthorOfPublicationfa89f42b-12a4-47bd-a4fb-0f65cbc06885
relation.isAuthorOfPublication.latestForDiscovery2361a951-8b9a-4b90-92d6-f6384003a242

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ftox-7-1719035.pdf
Size:
1.41 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
4.03 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

DGH - Artigos em revistas internacionais
INSA - Artigos em revistas internacionais