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Anti-corrosion and cytotoxicity properties of inorganic surface treatments on Mg1Ca biodegradable alloy

2025-02-01Artigo científico Acesso aberto
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dc.contributor.authorNeves, C.S.
dc.contributor.authorSousa, I.
dc.contributor.authorFreitas, M.A.
dc.contributor.authorMoreira, L.
dc.contributor.authorCosta, C.
dc.contributor.authorTeixeira, J.P.
dc.contributor.authorFraga, S.
dc.contributor.authorSilva, R.M.
dc.contributor.authorSilva, R.F.
dc.contributor.authorStarykevich, M.
dc.contributor.authorScharnagl, N.
dc.contributor.authorZheludkevich, M.L.
dc.contributor.authorFerreira, M.G.S.
dc.contributor.authorTedim, J.
dc.date.accessioned2026-02-03T15:28:28Z
dc.date.available2026-02-03T15:28:28Z
dc.date.issued2025-02-01
dc.description.abstractIn this work biodegradable Mg1Ca alloy underwent surface modification using hydroxyapatite (HAp), aluminium oxide (Al2O3), and treatments with phosphoric (H3PO4), hydrofluoric (HF), and acetic (CH3COOH) acids. The resulting surface-treated Mg substrates were assessed in terms of phase content and chemical composition through X-ray diffraction (XRD) and glow discharge optical emission spectrometry (GDOES). Additionally, atomic force microscopy (AFM) and scanning electron microscopy (SEM) were employed to examine the surface's topography and structure, while the corrosion behavior and cytotoxicity were surveyed using electrochemical impedance spectroscopy (EIS), alongside WST-1 reduction and lactate dehydrogenase (LDH) release assays on L929 mouse fibroblasts. The findings indicated that the surfaces of all samples were uniformly structured, while chemical analysis of the treated surfaces suggested the presence of mostly thin films. Furthermore, EIS results highlighted that the HAp-treated Mg1Ca alloy exhibited superior corrosion resistance, and the cytotoxicity assessment of Mg1Ca-HAp and Mg1Ca-H3PO4 alloys showed minimal cytotoxic effects on mouse fibroblasts, compared to other treated surfaces, suggesting enhanced biocompatibility of those two surface treatments. Overall, this constitutes the first comparative study of different surface treatments developed on biodegradable Mg1Ca alloy, aiming to identify optimal modification strategies for biomedical applications.eng
dc.description.abstractHighlights: -Different surface treatments were applied to biodegradable Mg1Ca. -Most treatments resulted in thin, amorphous films, which altered chemical composition and, in some cases, topography. -The best corrosion protection was achieved with hydroxyapatite conversion film. -Phosphoric acid and hydroxyapatite-based treatments showed the lowest cytotoxicity among the studied treatments.eng
dc.description.sponsorshipThis work was financed by Portugal 2020 through European Regional Development Fund (ERDF) in the frame of Operational Competitiveness and Internationalization Programme (POCI), in the scope of the project MAGICOAT POCI-01-0145-FEDER-016597/PTDC/CTM-BIO/2170/2014 and in the scope of the project CICECO-Aveiro Institute of Materials, UIDB/50011/2020 (DOI 10.54499/UIBD/50011/2020), UIDP/50011/2020 (DOI 10.54499/UIDP/50011/2020) & LA/P/0006/2020 (DOI 10.54499/LA/P/0006/2020), financed by national funds through the FCT/MCTES (PIDDAC). Furthermore, thanks are due to FCT/MCTES for the financial support through national funds to EPIUnit (UIDB/04750/2020) and ITR (LA/P/0064/2020)
dc.identifier.citationSurf Coat Technol. 2025 Feb 1;497:131704. doi: 10.1016/j.surfcoat.2024.131704
dc.identifier.doi10.1016/j.surfcoat.2024.131704
dc.identifier.eissn1879-3347
dc.identifier.issn0257-8972
dc.identifier.urihttp://hdl.handle.net/10400.18/10798
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationEpidemiology Research Unit - Institute of Public Health, University of Porto
dc.relationLaboratory for Integrative and Translational Research in Population Health
dc.relationLA/P/0064/2020
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S0257897224013367
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectMg1Ca Alloy
dc.subjectInorganic Surface Treatments
dc.subjectIn vitro Cytotoxicity
dc.subjectCorrosion
dc.subjectGenotoxicidade Ambiental
dc.titleAnti-corrosion and cytotoxicity properties of inorganic surface treatments on Mg1Ca biodegradable alloyeng
dc.typejournal article
dcterms.referenceshttps://ars.els-cdn.com/content/image/1-s2.0-S0257897224013367-mmc1.docx
dspace.entity.typePublication
oaire.awardTitleEpidemiology Research Unit - Institute of Public Health, University of Porto
oaire.awardTitleLaboratory for Integrative and Translational Research in Population Health
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04750%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0064%2F2020/PT
oaire.citation.startPage131704
oaire.citation.titleSurface and Coatings Technology
oaire.citation.volume497
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isProjectOfPublication05f4f337-eeba-4c07-82ed-4202b21618a2
relation.isProjectOfPublication18ca3cb0-ef66-4dd8-b45e-4cb0654cd7e8
relation.isProjectOfPublication.latestForDiscovery05f4f337-eeba-4c07-82ed-4202b21618a2

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