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Prevalence of Human Papillomavirus Infection in Women in Portugal - The CLEOPATRE Portugal Study

2011-08Journal article Restricted access
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dc.contributor.authorPista, Angela
dc.contributor.authorOliveira, Carlos
dc.contributor.authorCunha, Maria João
dc.contributor.authorPaixão, Teresa
dc.contributor.authorReal, Odete
dc.contributor.authorCLEOPATRE Portugal Study Group
dc.date.accessioned2013-02-13T13:33:32Z
dc.date.available2013-02-13T13:33:32Z
dc.date.issued2011-08
dc.description.abstractObjective: Human papillomavirus (HPV) is responsible for a range of diseases, including cervical cancer. The primary objectives of the CLEOPATRE Portugal study were to estimate the overall and age-stratified prevalence of cervical HPV infection, and to assess HPV prevalence and type-specific distribution by cytological results, among women aged 18–64 years resident in mainland Portugal. Methods/materials: This cross-sectional, population-based study recruited women aged 18–64 years, according to an age-stratified sampling strategy, who attended gynaecology/obstetrics or sexually transmitted disease clinics across the five Regional Health Administrations in mainland Portugal between 2008 and 2009. Liquid-based cytology samples were collected and analysed centrally for HPV genotyping (Clinical Array HPV 2 assay) and cytology. Prevalence estimates were adjusted for age using 2007 Portuguese census data. Results: A total of 2326 women were included in the study. The overall prevalence of HPV infection in the study was 19.4% (95% CI, 17.8–21.0), with the highest prevalence in women aged 18–24 years. High-risk HPV types were detected in 76.5% of infections, of which 36.6% involved multiple types. The commonest high-risk type was HPV 16. At least one of the HPV types 6/11/16/18 was detected in 32.6% of infections. The HPV prevalence in normal cytology samples was 16.5%. There was a statistically significant association between high-risk infection and cytological abnormalities (p<0.001). Conclusions: This is the first population-based study to quantify and describe cervical HPV infection in mainland Portugal. This study provides baseline data for future assessment of the impact of HPV vaccination programmes.por
dc.description.sponsorshipSanofi Pasteur MSDpor
dc.identifier.citationInt J Gynecol Cancer. 2011 Aug;21(6):1150-8por
dc.identifier.issn1048-891X
dc.identifier.issndoi: 10.1097/IGC.0b013e31821dd3b2
dc.identifier.urihttp://hdl.handle.net/10400.18/1330
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherLippincott, Williams & Wilkins/Wiley-Blackwellpor
dc.relation.publisherversionhttp://journals.lww.com/ijgc/pages/articleviewer.aspx?year=2011&issue=08000&article=00029&type=abstractpor
dc.subjectHuman Papillomaviruspor
dc.subjectPortugalpor
dc.subjectHPV Prevalencepor
dc.subjectHPV Genotypingpor
dc.subjectCitologypor
dc.titlePrevalence of Human Papillomavirus Infection in Women in Portugal - The CLEOPATRE Portugal Studypor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1158por
oaire.citation.startPage1150por
oaire.citation.titleInternational Journal of Gynecological Cancerpor
oaire.citation.volume21(6)por
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor

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