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A critical review to identify data gaps and improve risk assessment of bisphenol A alternatives for human health

2024-10-22Journal article Open access
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dc.contributor.authorMhaouty-Kodja, Sakina
dc.contributor.authorZalko, Daniel
dc.contributor.authorTait, Sabrina
dc.contributor.authorTestai, Emanuela
dc.contributor.authorViguié, Catherine
dc.contributor.authorCorsini, Emanuela
dc.contributor.authorGrova, Nathalie
dc.contributor.authorBuratti, Franca Maria
dc.contributor.authorCabaton, Nicolas J.
dc.contributor.authorCoppola, Lucia
dc.contributor.authorDe la Vieja, Antonio
dc.contributor.authorDusinska, Maria
dc.contributor.authorEl Yamani, Naouale
dc.contributor.authorGalbiati, Valentina
dc.contributor.authorIglesias-Hernández, Patricia
dc.contributor.authorKohl, Yvonne
dc.contributor.authorMaddalon, Ambra
dc.contributor.authorMarcon, Francesca
dc.contributor.authorNaulé, Lydie
dc.contributor.authorRundén-Pran, Elise
dc.contributor.authorSalani, Francesca
dc.contributor.authorSantori, Nicoletta
dc.contributor.authorTorres-Ruiz, Mónica
dc.contributor.authorTurner, Jonathan D.
dc.contributor.authorAdamovsky, Ondrej
dc.contributor.authorAiello-Holden, Kiara
dc.contributor.authorDirven, Hubert
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorSilva, Maria João
dc.date.accessioned2025-03-05T10:21:43Z
dc.date.available2025-03-05T10:21:43Z
dc.date.issued2024-10-22
dc.description.abstractBisphenol A (BPA), a synthetic chemical widely used in the production of polycarbonate plastic and epoxy resins, has been associated with a variety of adverse effects in humans including metabolic, immunological, reproductive, and neurodevelopmental effects, raising concern about its health impact. In the EU, it has been classified as toxic to reproduction and as an endocrine disruptor and was thus included in the candidate list of substances of very high concern (SVHC). On this basis, its use has been banned or restricted in some products. As a consequence, industries turned to bisphenol alternatives, such as bisphenol S (BPS) and bisphenol F (BPF), which are now found in various consumer products, as well as in human matrices at a global scale. However, due to their toxicity, these two bisphenols are in the process of being regulated. Other BPA alternatives, whose potential toxicity remains largely unknown due to a knowledge gap, have also started to be used in manufacturing processes. The gradual restriction of the use of BPA underscores the importance of understanding the potential risks associated with its alternatives to avoid regrettable substitutions. This review aims to summarize the current knowledge on the potential hazards related to BPA alternatives prioritized by European Regulatory Agencies based on their regulatory relevance and selected to be studied under the European Partnership for the Assessment of Risks from Chemicals (PARC): BPE, BPAP, BPP, BPZ, BPS-MAE, and TCBPA. The focus is on data related to toxicokinetic, endocrine disruption, immunotoxicity, developmental neurotoxicity, and genotoxicity/carcinogenicity, which were considered the most relevant endpoints to assess the hazard related to those substances. The goal here is to identify the data gaps in BPA alternatives toxicology and hence formulate the future directions that will be taken in the frame of the PARC project, which seeks also to enhance chemical risk assessment methodologies using new approach methodologies (NAMs).por
dc.description.sponsorshipAll authors developed the work in the course of their employment at their respective organizations and under the scope of the Partnership for the Assessment of Risks from Chemicals (PARC) that has received funding from the European Union’s Horizon Europe Research and Innovation Programme under Grant Agreement No. 101057014. The European Partnership for the Assessment of Risks from Chemicals has received funding from the European Union’s Horizon Europe Research and Innovation Programme under Grant Agreement No. 101057014. This work was also supported from the European Union’s Horizon 2020 Research and Innovation Programme under Grant Agreement No. 857560. The authors also acknowledge co-funding by their organizations and the following entities: Centre for Toxicogenomics and Human Health (ToxOmics), DOI 10.54499/UIDP/00009/2020 https://doi.org/10.54499/UIDP/00009/2020) and DOI 10.54499/UIDB/00009/2020 (https://doi.org/10.54499/UIDB/00009/2020); Spanish Ministerio de Ciencia e Innovacion (MICIN) and Fondo Europeo de Desarrollo Regional (FEDER) PID2021-125948OB-I00/AEI/10.13039/501100011033. Dr. Adamovsky thanks The Czech Science Foundation (GACR), Project 23-13617L, for support in plastic and plastic additives research.
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCrit Rev Toxicol. 2024 Nov;54(10):696-753. doi: 10.1080/10408444.2024.2388712. Epub 2024 Oct 22
dc.identifier.doi10.1080/10408444.2024.2388712pt_PT
dc.identifier.issn1040-8444
dc.identifier.urihttp://hdl.handle.net/10400.18/10406
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor and Francis Group
dc.relationEuropean Partnership for the Assessment of Risks from Chemicals (PARC)
dc.relationCETOCOEN Excellence
dc.relationCentre for Toxicogenomics and Human Health
dc.relationUIDB/00009/2020
dc.relation.hasversionhttps://www.tandfonline.com/doi/full/10.1080/10408444.2024.2388712
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectBisphenol A Alternativespt_PT
dc.subjectEndocrine Disruptionpt_PT
dc.subjectCarcinogenesispt_PT
dc.subjectDevelopmental Neurotoxicitypt_PT
dc.subjectHuman Healthpt_PT
dc.subjectImmunotoxicitypt_PT
dc.subjectMetabolismpt_PT
dc.subjectToxicokineticpt_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleA critical review to identify data gaps and improve risk assessment of bisphenol A alternatives for human healthpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEuropean Partnership for the Assessment of Risks from Chemicals (PARC)
oaire.awardTitleCETOCOEN Excellence
oaire.awardTitleCentre for Toxicogenomics and Human Health
oaire.awardURIhttp://hdl.handle.net/10400.18/10383
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/857560/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00009%2F2020/PT
oaire.citation.endPage753
oaire.citation.issue10
oaire.citation.startPage696
oaire.citation.titleCritical Reviews in Toxicology
oaire.citation.volume54
oaire.fundingStreamHorizon Europe Guarantee
oaire.fundingStreamH2020
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameLouro
person.familyNameSilva
person.givenNameHenriqueta
person.givenNameMaria Joao
person.identifier157627
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.ciencia-id7710-643D-97A3
person.identifier.orcid0000-0001-9744-7332
person.identifier.orcid0000-0002-6060-0716
person.identifier.scopus-author-id6507971479
person.identifier.scopus-author-id55944437600
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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