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Deoxynivalenol exposure assessment through a modelling approach of food intake and biomonitoring data – A contribution to the risk assessment of an enteropathogenic mycotoxin

2020-11-03Journal article Restricted access
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dc.contributor.authorMartins, Carla
dc.contributor.authorTorres, Duarte
dc.contributor.authorLopes, Carla
dc.contributor.authorCorreia, Daniela
dc.contributor.authorGoios, Ana
dc.contributor.authorAssunção, Ricardo
dc.contributor.authorAlvito, Paula
dc.contributor.authorVidal, Arnau
dc.contributor.authorDe Boevre, Marthe
dc.contributor.authorDe Saeger, Sarah
dc.contributor.authorNunes, Carla
dc.date.accessioned2021-03-15T15:52:58Z
dc.date.available2021-03-15T15:52:58Z
dc.date.issued2020-11-03
dc.description.abstractDeoxynivalenol (DON), an enteropathogenic mycotoxin produced by Fusarium species, is usually associated with adverse health outcomes such as gastrointestinal diseases and immunotoxicity. To estimate DON exposure of the Portuguese population at national level, a modelling approach, based on data from 94 Portuguese volunteers, was developed considering the inputs of the food consumption data generated within the National Food and Physical Activity Survey and the human biomonitoring data used to assess the exposure to DON. Ten models of association between DON urinary biomarkers and food items (pasta, cookies, biscuits, sweets, bread, rusks, nuts, oilseeds, beer, meat, milk) were established. Applying the most adequate model to the consumption data (n = 5811) of the general population, the exposure estimates of the Probable Daily Intake revealed that a fraction (0.1%) of the Portuguese population might exceed the Tolerable Daily Intake defined for DON. The analysis stratified by age revealed children (3.2%) and adolescents (6.0%) are more likely to exceed the Tolerable Daily Intake for DON. Although the unavoidable uncertainties, these results are important contributions to understand the exposure to this mycotoxin in Portugal, to assess the associated risk and the potential public health consequences.pt_PT
dc.description.sponsorshipThanks are due to FCT/MCTES for the financial support to CESAM (UIDP/50017/2020 + UIDB/50017/2020), through national funds. This research was also supported by the project MYTOX-SOUTH, a Ghent University Global Minds programme, and IAN-AF survey funded by the EEA Grants Program, Public Health Initiatives (PT06-000088SI3).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFood Res Int. 2021 Feb;140:109863. doi: 10.1016/j.foodres.2020.109863. Epub 2020 Nov 3.pt_PT
dc.identifier.doi10.1016/j.foodres.2020.109863pt_PT
dc.identifier.issn0963-9969
dc.identifier.urihttp://hdl.handle.net/10400.18/7497
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevier/ Canadian Institute of Food Science and Technology (CIFST)pt_PT
dc.relationCentre for Environmental and Marine Studies
dc.relationCentre for Environmental and Marine Studies
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/abs/pii/S0963996920308887?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectDeoxynivalenol (DON)pt_PT
dc.subjectMicotoxinspt_PT
dc.subjectModelingpt_PT
dc.subjectFood Comsuptionpt_PT
dc.subjectPublic Healthpt_PT
dc.subjectSegurança Alimentarpt_PT
dc.subjectAvaliação de Riscopt_PT
dc.subjectToxicologiapt_PT
dc.titleDeoxynivalenol exposure assessment through a modelling approach of food intake and biomonitoring data – A contribution to the risk assessment of an enteropathogenic mycotoxinpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50017%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50017%2F2020/PT
oaire.citation.startPage109863pt_PT
oaire.citation.titleFood Research Internationalpt_PT
oaire.citation.volume140pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication4e22de31-8fc5-4b15-b980-3fd0edf5515d
relation.isProjectOfPublication0e72e6c8-b610-43e0-931c-8ad275ad6093
relation.isProjectOfPublication.latestForDiscovery0e72e6c8-b610-43e0-931c-8ad275ad6093

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