Repository logo
 
Publication

Portuguese Lipid Study (e_LIPID)

2024-11Journal article Open access
Simple item page
dc.contributor.authorChora, Joana Rita
dc.contributor.authorAlves, Ana Catarina
dc.contributor.authorMariano, Cibelle
dc.contributor.authorRato, Quitéria
dc.contributor.authorAntunes, Marília
dc.contributor.authorBourbon, Mafalda
dc.date.accessioned2025-02-19T12:41:56Z
dc.date.available2025-02-19T12:41:56Z
dc.date.issued2024-11
dc.description.abstractBackground/Objectives: Incidence of cardiovascular disease (CVD) is increasing in low- and middle-income countries because of changing lifestyles. Since dyslipidaemia is a major independent cardiovascular risk factor, its correct identification is critical to implement specific interventions for CVD prevention. This study aimed to characterise the lipid profile of the Portuguese population. Methods: Overall, 1688 individuals from the general population (e_COR study, 2012-2014) were included. Population-specific percentiles for ten lipid biomarkers were estimated by bootstrapping methods to ensure national representativity. Statistical analyses were performed using RStudio. Results: The 50th percentile estimated for total cholesterol (TC), LDL-C, and non-HDL-C are similar to scientific societies recommended values for the general (low or moderate risk) population. National prevalence of having lipid parameters above recommended values was 64.6%, 66.9%, 51.3%, 68.9%, 17.8%, and 21.1% for TC, LDL-C, apoB, non-HDL-C, triglycerides, and Lp(a), respectively; these values are generally higher in men and increasing with age, except for Lp(a). A high prevalence of severe dyslipidaemia (>90th percentile) was identified, highest for small dense LDL-C (31.3%), apoB (30.4%), and LDL-C (30.3%). The national prevalence of CVD events was 5%. Three individuals were genetically identified with familial hypercholesterolemia, a high CVD risk condition. Conclusions: We provide for the first-time lipid biomarker percentiles for the general Portuguese population. Our results highlight that hypercholesterolemia is a neglected cardiovascular risk factor with over half of the population with TC, LDL-C, and apoB above recommended values. Since hypercholesterolemia is a modifiable risk factor, strategies to increase adherence to changes in lifestyle habits and medication need to be urgently discussed.pt_PT
dc.description.sponsorshipE_LIPID is a sub-study of the e_COR study, which was funded by the FCT—Fundação para a Ciência e a Tecnologia (PIC/IC/83020/2007). The authors also acknowledge a support for publication grant from Novartis Farma—Produtos Farmacêuticos, S.A, which enabled/supported the work developed by J. Chora. This grant was managed by FCiências.ID—Associação para a Investigação e Desenvolvimento de Ciências and its associated Research Unit CEAUL. The work by M. Antunes is partially financed by national funds through FCT—Fundação para a Ciência e a Tecnologia under the project UIDB/00006/2020 (DOI: 10.54499/UIDB/00006/2020).
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Clin Med. 2024 Nov 19;13(22):6965. doi: 10.3390/jcm13226965
dc.identifier.doi10.3390/jcm13226965pt_PT
dc.identifier.eissn2077-0383
dc.identifier.pmid39598108
dc.identifier.urihttp://hdl.handle.net/10400.18/10370
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPI
dc.relationPrevalence of Familial Hypercholesterolaemia and analysis of cardiovascular risk factors in the portuguese populution
dc.relationCentre of Statistics and its Applications
dc.relation.hasversionhttps://www.mdpi.com/2077-0383/13/22/6965
dc.relation.publisherversionhttps://www.mdpi.com/2077-0383/13/22/6965pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCardiovascular Risk Factorspt_PT
dc.subjectDyslipidaemiapt_PT
dc.subjectLipid Profilept_PT
dc.subjectLipid Percentilespt_PT
dc.subjectDoenças Cardio e Cérebro-vascularespt_PT
dc.titlePortuguese Lipid Study (e_LIPID)pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitlePrevalence of Familial Hypercholesterolaemia and analysis of cardiovascular risk factors in the portuguese populution
oaire.awardTitleCentre of Statistics and its Applications
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de Projectos de Investigação Científica e de Desenvolvimento Tecnológico no domínio da Investigação Clínica - 2007/PIC%2FIC%2F83020%2F2007/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00006%2F2020/PT
oaire.citation.issue22pt_PT
oaire.citation.startPage6965pt_PT
oaire.citation.titleJournal of Clinical Medicine
oaire.citation.volume13pt_PT
oaire.fundingStreamConcurso de Projectos de Investigação Científica e de Desenvolvimento Tecnológico no domínio da Investigação Clínica - 2007
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication9ae7f516-7d8a-4220-ad21-3d05560eb712
relation.isProjectOfPublication1828b27c-0dae-4001-a56b-8e520a5b181e
relation.isProjectOfPublication.latestForDiscovery1828b27c-0dae-4001-a56b-8e520a5b181e

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Joana_Chora_e_LIPID paper_publicado.pdf
Size:
1.67 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

DPSPDNT - Artigos em revistas internacionais
INSA - Artigos em revistas internacionais