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Hospitalization risk due to respiratory illness associated with genetic variation at IFITM3 in patients with influenza A(H1N1)pdm09 infection: a case-control study

2016-06-28Journal article Open access
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dc.contributor.authorGaio, Vânia
dc.contributor.authorNunes, Baltazar
dc.contributor.authorPechirra, Pedro
dc.contributor.authorConde, Patrícia
dc.contributor.authorGuiomar, Raquel
dc.contributor.authorDias, Carlos Matias
dc.contributor.authorBarreto, Marta
dc.date.accessioned2016-07-01T10:55:02Z
dc.date.available2016-07-01T10:55:02Z
dc.date.issued2016-06-28
dc.description.abstractRecent studies suggest an association between the Interferon Inducible Transmembrane 3 (IFITM3) rs12252 variant and the course of influenza infection. However, it is not clear whether the reported association relates to influenza infection severity. The aim of this study was to estimate the hospitalization risk associated with this variant in Influenza Like Illness (ILI) patients during the H1N1 pandemic influenza. A case-control genetic association study was performed, using nasopharyngeal/oropharyngeal swabs collected during the H1N1 pandemic influenza. Laboratory diagnosis of influenza infection was performed by RT-PCR, the IFITM3 rs12252 was genotyped by RFLP and tested for association with hospitalization. Conditional logistic regression was performed to calculate the confounder-adjusted odds ratio of hospitalization associated with IFITM3 rs12252. We selected 312 ILI cases and 624 matched non-hospitalized controls. Within ILI Influenza A(H1N1)pdm09 positive patients, no statistical significant association was found between the variant and the hospitalization risk (Adjusted OR: 0.73 (95%CI: 0.33–1.50)). Regarding ILI Influenza A(H1N1)pdm09 negative patients, CT/CC genotype carriers had a higher risk of being hospitalized than patients with TT genotype (Adjusted OR: 2.54 (95%CI: 1.54–4.19)). The IFITM3 rs12252 variant was associated with respiratory infection hospitalization but not specifically in patients infected with Influenza A(H1N1)pdm09.pt_PT
dc.identifier.citationPLoS One. 2016;11(6):e0158181. Epub 2016 Jun 28. doi: 10.1371/journal.pone.0158181.pt_PT
dc.identifier.doi10.1371/journal.pone.0158181pt_PT
dc.identifier.issn1932-6203
dc.identifier.otherESSN: 1932-6203
dc.identifier.urihttp://hdl.handle.net/10400.18/3868
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPublic Library of Sciencept_PT
dc.relation.publisherversionhttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0158181pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectInfluenza A(H1N1)pdm09pt_PT
dc.subjectGene IFITM3pt_PT
dc.subjectRespiratory Infectionspt_PT
dc.subjectHospitalization Riskpt_PT
dc.subjectPortuguese Influenza Surveillance Programpt_PT
dc.subjectPublic Health
dc.subjectPortugal
dc.subjectGripe
dc.subjectInfecções Respiratórias
dc.subjectRisco de Hospitalização
dc.subjectEstados de Saúde e de Doença
dc.titleHospitalization risk due to respiratory illness associated with genetic variation at IFITM3 in patients with influenza A(H1N1)pdm09 infection: a case-control studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceUniversity of Pittsburgh, United Statespt_PT
oaire.citation.titlePLOS ONEpt_PT
oaire.citation.volume6(11)pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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