Repository logo
 
Publication

Predicted strain coverage of a meningococcal multicomponent vaccine (4CMenB) in Portugal

2017-05-01Journal article Open access
Simple item page
dc.contributor.authorSimões, Maria João
dc.contributor.authorBettencourt, Célia
dc.contributor.authorDe Paola, Rosita
dc.contributor.authorGiuliani, Maria
dc.contributor.authorPizza, Mariagrazia
dc.contributor.authorMoschioni, Monica
dc.contributor.authorMachado, Jorge
dc.date.accessioned2018-03-05T17:17:54Z
dc.date.available2018-03-05T17:17:54Z
dc.date.issued2017-05-01
dc.description.abstractObjective: Although the incidence of meningococcal disease has been declining over the past decade in Portugal MenB meningococci is still an important cause of meningitis and sepsis. The aim of this study was to estimate the strain coverage of the 4CMenB vaccine in Portugal in order to support health policies for prevention and control of meningococcal disease. Methods: Since 2002 the clinical and laboratory notification of meningococcal disease is mandatory in Portugal. National database includes since then all confirmed cases notified to the reference laboratory or to the Directorate of Health. Strains included in this study were all the invasive MenB isolated from the 1st July 2011 to the 30th June 2015, sent to the reference laboratory. To predict the vaccine strain coverage of the 4CMenB the expression and cross-reactivity of the surface antigens fHbp, NadA, NHBA were assessed by the Meningococcal Antigen Typing System (MATS) whereas PorA typing was performed by sequencing. The presence of at least one antigen with a Relative Potency (RP) greater than its MATS-positive bactericidal threshold RP value or the presence of PorA VR2 = 4 was considered to be predictive for a strain to be covered by the 4CMenB vaccine. Results: The estimated 4CMenB strain coverage in Portugal was 67.9%. The percentage of strain coverage in each of the four epidemiological years ranged from 63.9% to 73.7%. Strains covered by one antigen represent 32.1% of the total of isolates, 29.2% of strains were covered by two antigens and 6.6% by three antigens. No strain had all the four antigens. Antigens that most contributed for coverage were NHBA and fHbp. Data from Portugal is in accordance with the MATS predicted strain coverage in five European countries (England and Wales, France, Germany, Italy and Norway) that pointed to 78% coverage for strains collected in the epidemiological year 2007-2008.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPLoS One. 2017 May 1;12(5):e0176177. doi: 10.1371/journal.pone.0176177. eCollection 2017.pt_PT
dc.identifier.doi10.1371/journal.pone.0176177pt_PT
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10400.18/5175
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPlosOnept_PT
dc.relation.publisherversionhttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0176177pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectMeningococci Group Bpt_PT
dc.subjectVaccinept_PT
dc.subjectStrain Coveragept_PT
dc.subjectNeisseria meningitidispt_PT
dc.subjectInfecções Respiratóriaspt_PT
dc.titlePredicted strain coverage of a meningococcal multicomponent vaccine (4CMenB) in Portugalpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue5pt_PT
oaire.citation.startPagee0176177pt_PT
oaire.citation.titlePLoS ONEpt_PT
oaire.citation.volume12pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Predicted strain coverage of a meningoc.pdf
Size:
3.43 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

DDI - Artigos em revistas internacionais