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Comparison of two methods for the estimation of COVID-19 vaccine effectiveness of the autumnal booster within the VEBIS-EHR network in 2022/23

2025-03-17Artigo científico Acesso aberto
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dc.contributor.authorMonge, Susana
dc.contributor.authorHumphreys, James
dc.contributor.authorNicolay, Nathalie
dc.contributor.authorBraeye, Toon
dc.contributor.authorVan Evercooren, Izaak
dc.contributor.authorHansen, Christian Holm
dc.contributor.authorEmborg, Hanne-Dorthe
dc.contributor.authorFabiani, Massimo
dc.contributor.authorSacco, Chiara
dc.contributor.authorCastilla, Jesús
dc.contributor.authorMartínez-Baz, Iván
dc.contributor.authorde Gier, Brechje
dc.contributor.authorHahné, Susan
dc.contributor.authorHinta Meijerink
dc.contributor.authorKristoffersen, Anja Bråthen
dc.contributor.authorMachado, Ausenda
dc.contributor.authorSoares, Patricia
dc.contributor.authorFontán-Vela, Mario
dc.contributor.authorNardone, Anthony
dc.contributor.authorKissling, Esther
dc.contributor.authorNunes, Baltazar
dc.contributor.authorVEBIS-Lot 4 working group
dc.date.accessioned2026-01-12T16:17:34Z
dc.date.available2026-01-12T16:17:34Z
dc.date.issued2025-03-17
dc.description.abstractWithin an infrastructure to monitor vaccine effectiveness (VE) against hospitalization due to COVID-19 and COVID-19 related deaths from November 2022 to July 2023 in seven countries in real-world conditions (VEBIS network), we compared two approaches: (a) estimating VE of the first, second or third COVID-19 booster doses administered during the autumn of 2022, and (b) estimating VE of the autumn vaccination dose regardless of the number of prior doses (autumnal booster approach). Retrospective cohorts were constructed using Electronic Health Records at each participating site. Cox regressions with time-changing vaccination status were fit and site-specific estimates were combined using random-effects meta-analysis. VE estimates with both approaches were mostly similar, particularly shortly after the start of the vaccination campaign, and showed a similar timing of VE waning. However, autumnal booster estimates were more precise and showed a clearer trend, particularly compared to third booster estimates, as calendar time increased after the vaccination campaign and during periods of lower SARS-CoV-2 activity. Moreover, the decrease in protection by increasing calendar time was more clear and precise than when comparing protection by number of doses. Therefore, estimating VE under an autumnal booster framework emerges as a preferred method for future monitoring of COVID-19 vaccination campaigns.eng
dc.description.sponsorshipAll the public health organizations involved received funding from the European Centre for Disease Prevention and Control (ECDC) implementing Framework Contract ECDC/2021/018 ‘Vaccine effectiveness and impact of COVID-19 vaccines through routinely collected exposure and outcome using health registries’ (RS/2022/DTS/24104). In Portugal, this work was also supported by FCT – Fundação para a Ciência e Tecnologia, I.P. by project reference CEECINST/00049/2021/CP2817/CT0001 and DOI identifier 10.54499/CEECINST/00049/2021/CP2817/CT0001.
dc.identifier.citationEpidemiol Infect. 2025 Mar 17:153:e54. doi: 10.1017/S0950268825000317
dc.identifier.doi10.1017/s0950268825000317
dc.identifier.issn0950-2688
dc.identifier.issn1469-4409
dc.identifier.pmid40090768
dc.identifier.urihttp://hdl.handle.net/10400.18/10679
dc.language.isoeng
dc.peerreviewedyes
dc.publisherCambridge University Press
dc.relationCEECINST/00049/2021/CP2817/CT000
dc.relation.hasversionhttps://www.cambridge.org/core/journals/epidemiology-and-infection/article/comparison-of-two-methods-for-the-estimation-of-covid19-vaccine-effectiveness-of-the-autumnal-booster-within-the-vebisehr-network-in-202223/5C9A63B7A70B2C4FA9F9096050025053
dc.relation.ispartofEpidemiology and Infection
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subjectCohort Design
dc.subjectCOVID-19
dc.subjectElectronic Health Records
dc.subjectHospitalization
dc.subjectMulti-Country Study
dc.subjectSARS-CoV-2
dc.subjectVaccine Effectiveness
dc.subjectVEBIS
dc.subjectSARS-CoV-2
dc.subjectVaccine Effectiveness
dc.subjectEstados de Saúde e de Doença
dc.subjectInfecções Respiratórias
dc.titleComparison of two methods for the estimation of COVID-19 vaccine effectiveness of the autumnal booster within the VEBIS-EHR network in 2022/23eng
dc.typejournal article
dcterms.referenceshttps://www.cambridge.org/core/journals/epidemiology-and-infection/article/comparison-of-two-methods-for-the-estimation-of-covid19-vaccine-effectiveness-of-the-autumnal-booster-within-the-vebisehr-network-in-202223/5C9A63B7A70B2C4FA9F9096050025053#supplementary-materials-tab
dspace.entity.typePublication
oaire.citation.startPagee54
oaire.citation.titleEpidemiology & Infection
oaire.citation.volume153
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameMachado
person.familyNameSoares
person.familyNameNunes
person.givenNameAusenda
person.givenNamePatricia
person.givenNameBaltazar
person.identifier1050496
person.identifier.ciencia-id1217-6076-5D88
person.identifier.ciencia-id0415-632D-8609
person.identifier.ciencia-idAB11-AD48-A8DF
person.identifier.orcid0000-0002-1849-1499
person.identifier.orcid0000-0001-5033-9115
person.identifier.orcid0000-0001-6230-7209
person.identifier.scopus-author-id52063758300
person.identifier.scopus-author-id9133723200
relation.isAuthorOfPublication544ad266-0c22-4a50-9ebc-86acc08d6666
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relation.isAuthorOfPublication.latestForDiscovery544ad266-0c22-4a50-9ebc-86acc08d6666

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