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Variants of the Matrix Metalloproteinase-2 but not the Matrix Metalloproteinase-9 genes significantly influence functional outcome after stroke

2010-03-11Journal article Open access
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dc.contributor.authorManso, H.
dc.contributor.authorKrug, T.
dc.contributor.authorSobral, J.
dc.contributor.authorAlbergaria, I.
dc.contributor.authorGaspar, G.
dc.contributor.authorFerro, J.M.
dc.contributor.authorOliveira, S.A.
dc.contributor.authorVicente, A.M.
dc.date.accessioned2011-09-26T12:03:28Z
dc.date.available2011-09-26T12:03:28Z
dc.date.issued2010-03-11
dc.description.abstractMultiple lines of evidence suggest that genetic factors contribute to stroke recovery. The matrix metalloproteinases -2 (MMP-2) and -9 (MMP-9) are modulators of extracellular matrix components, with important regulatory functions in the Central Nervous System (CNS). Shortly after stroke, MMP-2 and MMP-9 have mainly damaging effects for brain tissue. However, MMPs also have a beneficial activity in angiogenesis and neurovascular remodelling during the delayed neuroinflammatory response phase, thus possibly contributing to stroke functional recovery.por
dc.identifier.citationBMC Med Genet. 2010 Mar 11;11:40por
dc.identifier.issn1471-2350
dc.identifier.otherdoi: 10.1186/1471-2350-11-40
dc.identifier.urihttp://hdl.handle.net/10400.18/233
dc.language.isoengpor
dc.publisherBioMed Centralpor
dc.relation.publisherversionhttp://www.biomedcentral.com/1471-2350/11/40por
dc.subjectDoenças Cardio e Cérebro-vascularespor
dc.titleVariants of the Matrix Metalloproteinase-2 but not the Matrix Metalloproteinase-9 genes significantly influence functional outcome after strokepor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleBMC Medical Geneticspor
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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