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Indirect effect of 7-valent and 13-valent pneumococcal conjugated vaccines on pneumococcal pneumonia hospitalizations in elderly

2019-01-16Journal article Open access
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dc.contributor.authorKislaya, Irina
dc.contributor.authorRodrigues, Ana Paula
dc.contributor.authorSousa-Uva, Mafalda
dc.contributor.authorGómez, Verónica
dc.contributor.authorGonçalves, Paulo
dc.contributor.authorFroes, Filipe
dc.contributor.authorNunes, Baltazar
dc.date.accessioned2019-01-18T10:43:12Z
dc.date.available2019-01-18T10:43:12Z
dc.date.issued2019-01-16
dc.description.abstractBackground: Pneumonia is one of the leading causes of mortality and has a high burden in morbidity. In Portugal, 7-valent pneumococcal conjugated vaccine (PCV) was used since 2001 and PCV10/13 since 2009, being the last introduced into the National Immunization Program in 2015. Methods: We conducted an ecological study to evaluate the impact of PCV7 and PCV13 on pneumococcal pneumonia (PP) hospitalizations in adults aged 65 years or more in Portugal. National hospital discharge registry data from 1998/99 to 2015/16 were used, and PP hospitalization was defined as any hospitalization coded in primary diagnosis as 481 (ICD-9-CM) or J18 (ICD-10-CM). Poisson regression models adjusted for seasonality, influenza-like illness and allowing for overdispersion was used to estimate annual average change of PP hospitalization rate. To assess PP hospitalization trends before and after PCV7 and PCV13 introduction interrupted time series analysis was performed. Results: In 1998/99 PP hospitalization rate was 7.0 per 10,000 inhabitants, varying between 3.2 (females, 65-74 years) to 20.7 (males, +85 years), and annually increasing by 16% during the pre-PCV7 period. Statistically significant reduction of 14% per year in PP hospitalization rate was observed after PCV7 introduction. Between 2004/05 and 2009/10 PP hospitalization rate decreased annually by 4% and after PCV13 introduction by 11% per year. In 2015/16 we found an overall reduction of 2.9 (CI 95%: 2.7; 3.1) PP hospitalizations per 10,000 inhabitants (598 hospitalizations) attributable to PCV13, varying from 2.2 (CI 95%: 1.3; 3.1) (female, 65-74 years) to 5.6 (CI 95%: 3.8; 7.5) (female, +85 years). Conclusions: Our results suggest that introduction of both PCV7 and PCV13 vaccines resulted in the reduction of PP hospitalizations rates among older adults.pt_PT
dc.description.sponsorshipThe IMOVE+ project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 634446pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPLoS One. 2019 Jan 16;14(1):e0209428. doi: 10.1371/journal.pone.0209428. eCollection 2019pt_PT
dc.identifier.doi10.1371/journal.pone.0209428pt_PT
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10400.18/5703
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPublic Library of Sciencept_PT
dc.relationI-MOVE+ Integrated Monitoring of Vaccines Effects in Europe: a platform to measure and compare effectiveness and impact of influenza and pneumococcal vaccines and vaccination strategies in the elderly
dc.relation.publisherversionhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209428pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPneumococcal Conjugate Vaccinept_PT
dc.subjectPneumococcal Pneumoniapt_PT
dc.subjectHospitalizationpt_PT
dc.subjectVacina Pneumocócica Conjugadapt_PT
dc.subjectPneumonia Pneumocócicapt_PT
dc.subjectEstados de Saúde e de Doençapt_PT
dc.subjectDeterminantes da Saúde e da Doençapt_PT
dc.subjectSaúde Públicapt_PT
dc.subjectPortugalpt_PT
dc.titleIndirect effect of 7-valent and 13-valent pneumococcal conjugated vaccines on pneumococcal pneumonia hospitalizations in elderlypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleI-MOVE+ Integrated Monitoring of Vaccines Effects in Europe: a platform to measure and compare effectiveness and impact of influenza and pneumococcal vaccines and vaccination strategies in the elderly
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/634446/EU
oaire.citation.issue14pt_PT
oaire.citation.startPagee0209428pt_PT
oaire.citation.titlePLoS ONEpt_PT
oaire.citation.volume1pt_PT
oaire.fundingStreamH2020
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationccfd73a6-6f3c-4702-956c-544973bca97d
relation.isProjectOfPublication.latestForDiscoveryccfd73a6-6f3c-4702-956c-544973bca97d

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