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Occupational exposure to Hexavalent chromium: the portuguese case within the collaborative european human biological monitoring study

2019-08-29Conference object Restricted access
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dc.contributor.authorAfonso, Catarina
dc.contributor.authorGomes, Bruno Costa
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorLadeira, Carina
dc.contributor.authorPinhal, Hermínia
dc.contributor.authorNogueira, Ana
dc.contributor.authorSantos, Sílvia
dc.contributor.authorVentura, Célia
dc.contributor.authorRibeiro, Edna
dc.contributor.authorSantonen, Tiina
dc.contributor.authorViegas, Susana
dc.contributor.authorSilva, Maria João
dc.date.accessioned2020-05-23T10:54:13Z
dc.date.available2020-05-23T10:54:13Z
dc.date.issued2019-08-29
dc.description.abstractBackground: The EU human biomonitoring initiative (HBM4EU) aims to coordinate and advance human biomonitoring across Europe. A multicenter study intending to characterize occupational exposure to hexavalent chromium [Cr(VI)], a human carcinogen, was setup in several industrial settings across Europe. In Portugal, the study was developed in one aircraft maintenance company since the substitution of Cr(VI) in this sector is not expected in the near future. Methods: The work processes that could imply exposure to Cr(VI) were characterized and exposure estimation was done. Following the company agreement and the volunteers informed consent, a survey was applied to each worker for detailed information on lifestyle, health status, etc.. Sampling for exposure and effect biomarkers analyses involved industrial hygiene samples (HIS) and biological specimens from 50 workers and 25 non-exposed individuals (controls). Biomarkers of early biological effects were studied in leukocytes from all individuals, involving the analysis of DNA damage (comet assay) and chromosome alterations (micronucleus assays); the results obtained for exposed and control individuals were statistically compared. Results and Discussion: Besides HIS results, Cr (VI) concentrations in biological samples and effect biomarkers results will be presented. The complementarity of the environmental and biological sampling, together with the sensitivity and specificity of the biomarkers used, is expected to allow exposure characterization and possible early genotoxic effects identification. Potential associations between exposure and effect biomarkers will be explored. Conclusions: An association between the levels of exposure to Cr(VI) and the early effects characterized in workers, if existent, is expected to predict potential health outcomes for Cr(VI)-exposed workers, particularly, on the long-term. All the information generated will help to support new priorities and investments regarding risk management measures to apply in this company and in the aircraft maintenance sector, in general.pt_PT
dc.description.sponsorshipThis project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No 733032 HBM4EU.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/6766
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationEuropean Human Biomonitoring Initiative
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectHuman Biomonitoringpt_PT
dc.subjectHexavalent Chromiumpt_PT
dc.subjectEffect Biomarkerspt_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleOccupational exposure to Hexavalent chromium: the portuguese case within the collaborative european human biological monitoring studypt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleEuropean Human Biomonitoring Initiative
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/733032/EU
oaire.citation.conferencePlaceLeuven, Bélgicapt_PT
oaire.citation.title11th International Symposium on Biological Monitoring in Occupational and Environmental Health (ISBM-11), 28-30 August 2019pt_PT
oaire.fundingStreamH2020
person.familyNameGomes
person.familyNameLouro
person.familyNameVentura
person.familyNameSilva
person.givenNameBruno
person.givenNameHenriqueta
person.givenNameCélia
person.givenNameMaria Joao
person.identifier157627
person.identifier2056460
person.identifier.ciencia-id1110-883F-9181
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.ciencia-id6116-89BA-C617
person.identifier.ciencia-id7710-643D-97A3
person.identifier.orcid0000-0002-5632-1095
person.identifier.orcid0000-0001-9744-7332
person.identifier.orcid0000-0002-0637-2222
person.identifier.orcid0000-0002-6060-0716
person.identifier.scopus-author-id6507971479
person.identifier.scopus-author-id55944437600
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsembargoedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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