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Bacterial biofilms, antibiotic resistance and healthcare-associated infections: a dangerous connection
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Orientador(es)
Resumo(s)
In 2012, were estimated 6.7 million cases of healthcare-associated infections (HAI) either in long-term care
facilities or acute-care hospitals from which result 37,000 deaths configuring a serious public health problem.
The etiological agents are diverse and often resistant to antimicrobial drugs. One of the mechanisms
responsible for the emergence of drug resistance is biofilm assembly. Biofilms are defined as thin layers of
microorganisms adhering to the surface of a structure, which may be organic or inorganic, together with the
polymers that they secrete. They are dynamic structures which experience different stages of organization
with the ageing and are linked to an increase in bacterial resistance to host defense mechanisms, antibiotics,
sterilization procedures other than autoclaving, persistence in water distribution systems and other surfaces.
The understanding of bacteria organization within the biofilm and the identification of differences between
planktonic and sessile forms of bacteria will be a step forward to fight HAIs.
Descrição
Palavras-chave
Biofilms Antibiotic Resistance Healthcare-associated Infections (HAI)
Contexto Educativo
Citação
Microsc. Microanal.2015;21(Suppl 6):38-39. doi:10.1017/S1431927614013865
Editora
Cambridge Journals Press/Microscopy Society of America